M
Marcela Vejsova
Researcher at Charles University in Prague
Publications - 36
Citations - 1021
Marcela Vejsova is an academic researcher from Charles University in Prague. The author has contributed to research in topics: Antimycobacterial & Lipophilicity. The author has an hindex of 18, co-authored 33 publications receiving 853 citations. Previous affiliations of Marcela Vejsova include Cork Institute of Technology.
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Journal ArticleDOI
Investigating biological activity spectrum for novel styrylquinazoline analogues.
Josef Jampilek,Robert Musiol,Jacek Finster,Matus Pesko,James Carroll,Katarina Kralova,Marcela Vejsova,Jim O'Mahony,Aidan Coffey,Jiri Dohnal,Jaroslaw Polanski +10 more
TL;DR: The structure-activity relationships (SAR) between the chemical structure and biological effects of the synthesized compounds are described and the relationships between the RP-HPLC retention parameter logK (the logarithm of capacity factor K) and logP data calculated by available programs are illustrated.
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Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis.
Galina Karabanovich,Júlia Zemanová,Tomáš Smutný,Rita Székely,Michal Šarkan,Ivana Centárová,Anthony Vocat,Ivona Pavkova,Patrik Čonka,Jan Němeček,Jiřina Stolaříková,Marcela Vejsova,Kateřina Vávrová,Věra Klimešová,Alexandr Hrabálek,Petr Pavek,Stewart T. Cole,Katarína Mikušová,Jaroslav Roh +18 more
TL;DR: The oxadiazole and thiadiazoles derivatives with the most favorable activity/toxicity profiles showed potency comparable to that of rifampicin against the nonreplicating streptomycin-starved M. tuberculosis 18b-Lux strain, and therefore, these derivatives, are of particular interest.
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Identification and characterization of thiosemicarbazones with antifungal and antitumor effects: cellular iron chelation mediating cytotoxic activity.
Veronika Opletalova,Danuta S. Kalinowski,Marcela Vejsova,Jiří Kuneš,Milan Pour,Josef Jampilek,Vladimír Buchta,Des R. Richardson +7 more
TL;DR: In contrast to other thiosemicarbazones with potent antiproliferative activity, Fe chelation and mobilization rather than free radical generation played a significant role in the cytotoxic effects of the current ligands.
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Contribution to investigation of antimicrobial activity of styrylquinolines.
Wioleta Cieslik,Robert Musiol,Jacek E. Nycz,Josef Jampilek,Marcela Vejsova,Mariusz Wolff,Barbara Machura,Jaroslaw Polanski +7 more
TL;DR: Series of new ring-substituted styrylquinolines and two oxorhenium complexes prepared and characterized expressed excellent antifungal activity and antibacterial activity against Staphylococcus strains comparable with or higher than the standards bacitracin, penicillin and ciprofloxacin.
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Ring-substituted 4-hydroxy-1H-quinolin-2-ones: preparation and biological activity.
Josef Jampilek,Robert Musiol,Matus Pesko,Katarina Kralova,Marcela Vejsova,James Carroll,Aidan Coffey,Jacek Finster,Dominik Tabak,Halina Niedbala,Violetta Kozik,Jaroslaw Polanski,Jozef Csöllei,Jiri Dohnal +13 more
TL;DR: In the study, a series of twelve ring-substituted 4-hydroxy-1H-quinolin-2-one derivatives were prepared and the relationships between the lipophilicity and the chemical structure of the studied compounds are discussed, as well as their structure-activity relationships (SAR).