J
Jack P. Antel
Researcher at Montreal Neurological Institute and Hospital
Publications - 540
Citations - 49656
Jack P. Antel is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Multiple sclerosis & Microglia. The author has an hindex of 105, co-authored 519 publications receiving 43950 citations. Previous affiliations of Jack P. Antel include Université de Montréal & Howard Hughes Medical Institute.
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Journal ArticleDOI
Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic.
Maryam Sharifian-Dorche,Philippe Huot,Michael Osherov,Dingke Wen,Alexander Saveriano,Paul S. Giacomini,Jack P. Antel,Ashkan Mowla +7 more
TL;DR: The most common neurological complaints in COVID-19 were anosmia, ageusia, and headache, but more serious complications, such as stroke, impairment of consciousness, seizures, and encephalopathy, have also been reported.
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Central nervous system-directed effects of FTY720 (fingolimod).
TL;DR: Animal model studies indicate an overall neuroprotective effect of FTY720 mediated at least in part by its actions within the CNS across the broad clinical spectrum of MS.
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Axonal metabolic recovery in multiple sclerosis patients treated with interferon β-1b
Sridar Narayanan,Nicola De Stefano,Gordon S. Francis,Rozie Arnaoutelis,Zografos Caramanos,D. Louis Collins,Daniel Pelletier,Barry G. W. Arnason,Jack P. Antel,Douglas L. Arnold +9 more
TL;DR: The data suggest that, in addition to losing axons, patients with chronic multiple sclerosis suffer from chronic, sublethal axonal injury that is at least partially reversible with interferon β–1b therapy.
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Reactive microglia in multiple sclerosis lesions have an increased expression of receptors for the Fc part of IgG.
Elling Ulvestad,Kenneth C. Williams,Christian A. Vedeler,Jack P. Antel,Harald Nyland,Sverre Mørk,Roald Matre +6 more
TL;DR: The FcR on microglia and perivascular macrophages may be of functional importance in antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, and local immunoregulation, and F cR on endothelium May be of importance in binding and transportation of immune complexes into the CNS.
Journal Article
MHC Class I-Restricted Lysis of Human Oligodendrocytes by Myelin Basic Protein Peptide-Specific CD8 T Lymphocytes
TL;DR: The results support the postulate that autoreactive CD8 cytotoxic T cells can contribute to the tissue injury in MS.