J
Jack P. Antel
Researcher at Montreal Neurological Institute and Hospital
Publications - 540
Citations - 49656
Jack P. Antel is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Multiple sclerosis & Microglia. The author has an hindex of 105, co-authored 519 publications receiving 43950 citations. Previous affiliations of Jack P. Antel include Université de Montréal & Howard Hughes Medical Institute.
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Journal ArticleDOI
Multiple sclerosis flares associated with recombinant granulocyte colony-stimulating factor
Harry Openshaw,Olaf Stüve,Jack P. Antel,Richard A. Nash,Brett T. Lund,Leslie P. Weiner,Ashwin Kashyap,Peter A. McSweeney,Stephen J. Forman +8 more
TL;DR: Four patients who were enrolled on protocols of high-dose immunosuppression with peripheral blood stem cell rescue for MS experienced neurologic worsening while receiving recombinant human granulocyte colony-stimulating factor, and there was improvement when methylprednisolone was given to three of the patients.
Journal ArticleDOI
ADP and AMP Induce Interleukin-1β Release from Microglial Cells through Activation of ATP-Primed P2X7 Receptor Channels
Yassar Chakfe,Rosanne Seguin,Jack P. Antel,Céline Morissette,Danielle Malo,Duncan Henderson,Philippe Séguéla +6 more
TL;DR: It is concluded that selective sensitization of P2X7 receptors to ADP and AMP requires priming with ATP, which leads to activation by ATP metabolites and proinflammatory cytokine release from microglia without cytotoxicity.
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Relating axonal injury to functional recovery in MS
H. Reddy,Sridar Narayanan,Paul M. Matthews,Richard D. Hoge,G.B. Pike,Pierre Duquette,Jack P. Antel,Douglas L. Arnold +7 more
TL;DR: The association of clinical improvement with recovery of N-acetylaspartate, a marker of neuronal integrity, and progressive reduction of abnormally large functional MRI cortical activation with movement demonstrates that dynamic reorganization of the motor cortex accompanies remission of MS.
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Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity.
Heinz Wiendl,Ute Feger,Michel Mittelbronn,Carolyn Jack,Bettina Schreiner,Christine Stadelmann,Jack P. Antel,Wolfgang Brueck,Richard Meyermann,Amit Bar-Or,Bernd C. Kieseier,Michael Weller +11 more
TL;DR: The demonstration of HLA-G and its receptor ILT2 on CNS cells and in areas of microglia activation implicate HLA -G as a contributor to the fundamental mechanisms regulating immune reactivity in the CNS.
Journal ArticleDOI
Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells
Cha-Gyun Jung,Hye-Jung Kim,Veronique E. Miron,S Cook,Timothy E. Kennedy,C A Foster,Jack P. Antel,Betty Soliven +7 more
TL;DR: S1P1 and S1P5 serve different functions during oligodendroglial development, and possibly during remyelination, as well as being differentially modulated by platelet‐derived growth factor (PDGF) and PDGF‐induced OPC mitogenesis.