J
Jack P. Antel
Researcher at Montreal Neurological Institute and Hospital
Publications - 540
Citations - 49656
Jack P. Antel is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Multiple sclerosis & Microglia. The author has an hindex of 105, co-authored 519 publications receiving 43950 citations. Previous affiliations of Jack P. Antel include Université de Montréal & Howard Hughes Medical Institute.
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Journal ArticleDOI
Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation.
Lior Mayo,Sunia A. Trauger,Manon Blain,Meghan Nadeau,Bonny Patel,Jorge I. Alvarez,Ivan D. Mascanfroni,Ada Yeste,Pia Kivisäkk,Keith Kallas,Benjamin Ellezam,Rohit Bakshi,Alexandre Prat,Jack P. Antel,Howard L. Weiner,Francisco J. Quintana +15 more
TL;DR: It is reported that lactosylceramide synthesized by β-1,4-galactosyltransferase 6 (B4GALT6) is upregulated in the central nervous system of mice during chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS).
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A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response
Walther Haenseler,Stephen N. Sansom,Julian Buchrieser,Sarah E. Newey,Craig S. Moore,Francesca J. Nicholls,Satyan Chintawar,Christian Schnell,Jack P. Antel,Nicholas D. Allen,M Z Cader,Richard Wade-Martins,William James,Sally A. Cowley +13 more
TL;DR: Co-culture microglia downregulate pathogen-response pathways, upregulate homeostatic function pathways, and promote a more anti-inflammatory and pro-remodeling cytokine response than corresponding monocultures, demonstrating that co-cultures are preferable for modeling authentic microglial physiology.
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Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques.
TL;DR: It is proposed that abnormal signals from choline can indicate recent regional demyelination, while persistent abnormal signalsfrom N‐acetylaspartate can provide an index of irreversible damage in the nervous system.
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Glial cell influence on the human blood-brain barrier.
TL;DR: Glial cells that become activated in response to signals derived from the immune system or generated within the CNS, produce an array of inflammatory molecules that increase permeability and promote lymphocyte trafficking and persistence, emphasizing the bidirectional nature of neural‐immune interactions.
Journal ArticleDOI
Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype.
Konrad Gabrusiewicz,Benjamin Rodriguez,Jun Wei,Yuuri Hashimoto,Luke M. Healy,Sourindra Maiti,Ginu Thomas,Shouhao Zhou,Qianghu Wang,Ahmed Elakkad,Brandon D. Liebelt,Nasser K. Yaghi,Ravesanker Ezhilarasan,Neal Huang,Jeffrey S. Weinberg,Sujit S. Prabhu,Ganesh Rao,Raymond Sawaya,Lauren A. Langford,Janet M. Bruner,Gregory N. Fuller,Amit Bar-Or,Wei Li,Rivka R. Colen,Michael A. Curran,Krishna P. Bhat,Jack P. Antel,Laurence J.N. Cooper,Erik P. Sulman,Amy B. Heimberger +29 more
TL;DR: G GAM profiling using flow cytometry studies revealed a continuum between the M1- and M2-like phenotype, and contrary to current dogma, GAMs exhibited distinct immunological functions, with the former aligned close to nonpolarized M0 macrophages.