J
Jack P. Antel
Researcher at Montreal Neurological Institute and Hospital
Publications - 540
Citations - 49656
Jack P. Antel is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Multiple sclerosis & Microglia. The author has an hindex of 105, co-authored 519 publications receiving 43950 citations. Previous affiliations of Jack P. Antel include Université de Montréal & Howard Hughes Medical Institute.
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Diminished Th17 (not Th1) responses underlie multiple sclerosis disease abrogation after hematopoietic stem cell transplantation.
Peter J. Darlington,Tarik Touil,Jean Sebastien Doucet,Denis Gaucher,Joumana Zeidan,Dominique Gauchat,Rachel Corsini,Ho Jin Kim,Martin Duddy,Farzaneh Jalili,Nathalie Arbour,Hania Kebir,Jacqueline T. Chen,Douglas L. Arnold,Marjorie A. Bowman,Jack P. Antel,Alexandre Prat,Mark S. Freedman,Harold L. Atkins,Rafick Pierre Sekaly,Rémi Cheynier,Rémi Cheynier,Rémi Cheynier,Amit Bar-Or +23 more
TL;DR: In this article, the authors defined changes in phenotype and functional responses of reconstituting T cells in patients with aggressive multiple sclerosis (MS) treated with ablative chemotherapy and autologous hematopoietic stem cell transplantation (HSCT).
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Migration of multiple sclerosis lymphocytes through brain endothelium.
Alexandre Prat,Katarzyna Biernacki,Jean-Francois Lavoie,Josée Poirier,Pierre Duquette,Jack P. Antel +5 more
TL;DR: The results demonstrate an increased migration rate of MS T lymphocytes across the brain endothelium barrier and that such migration is dependent on chemokine monocyte chemoattractant protein 1 and on matrix metalloproteinases.
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Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis
TL;DR: Functional antagonism of S1P1 by fingolimod results in a reduction in peripheral lymphocyte counts by inhibiting egress of lymphocytes, including potentially encephalitogenic T cells and their naïve progenitors that would otherwise be present within the circulation.
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Phenotypic differences between human monocytes/macrophages and microglial cells studied in situ and in vitro
TL;DR: The results indicate that invading monocytes/macrophages mainly have a perivascular location in active multiple sclerosis lesions, whereas invading monocyte/ Macrophages also infiltrate the parenchyma in acute inflammatory CNS diseases such as in encephalitis.
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Statin Therapy Inhibits Remyelination in the Central Nervous System
Veronique E. Miron,Simone P. Zehntner,Tanja Kuhlmann,Samuel K. Ludwin,Trevor Owens,Timothy E. Kennedy,Barry J. Bedell,Jack P. Antel +7 more
TL;DR: The findings suggest that simvastatin inhibits central nervous system remyelination by blocking progenitor differentiation, indicating the need to monitor effects of systemic immunotherapies that can access the central nervous System on brain tissue-repair processes.