J
Jackie R. Vandenheede
Researcher at Katholieke Universiteit Leuven
Publications - 108
Citations - 7906
Jackie R. Vandenheede is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Phosphatase & Protein kinase A. The author has an hindex of 48, co-authored 108 publications receiving 7750 citations. Previous affiliations of Jackie R. Vandenheede include The Catholic University of America & Catholic University of Leuven.
Papers
More filters
Journal ArticleDOI
Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau
Eckhard Mandelkow,Gerard Drewes,Jacek Biernat,N. Gustke,J Van Lint,Jackie R. Vandenheede,Eckhard Mandelkow +6 more
TL;DR: It is shown that the proline‐directed kinase, GSK3, can induce an Alzheimer‐like immune response involving several distinct and phoshorylatable epitopes at Ser—Pro motifs, as well as gel mobility shift, similar to MAP kinase.
Journal ArticleDOI
The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf
Darren Cross,Dario R. Alessi,Jackie R. Vandenheede,H E McDowell,Harinder S. Hundal,Philip Cohen +5 more
TL;DR: In this article, the authors showed that GSK3 isoforms are inhibited by 40% within minutes after stimulation of the rat skeletal-muscle cell line L6 with insulin-like growth factor-1 (IGF-1) or insulin.
Journal ArticleDOI
Glycogen Synthase Kinase-3β Phosphorylates Protein Tau and Rescues the Axonopathy in the Central Nervous System of Human Four-repeat Tau Transgenic Mice
Kurt Spittaels,Chris Van den Haute,Jo Van Dorpe,Hugo Geerts,Marc Mercken,Koen Bruynseels,Reena Lasrado,Kris Vandezande,Isabelle Laenen,Tim Boon,Johan Van Lint,Jackie R. Vandenheede,Diederik Moechars,Ruth J. F. Loos,Fred Van Leuven +14 more
TL;DR: It is demonstrated that GSK-3β reduces the number of axonal dilations and alleviates the motoric impairment that was typical for single htau40 transgenic animals, and could have therapeutic implications in the field of neurodegeneration.
Journal ArticleDOI
Gβγ-Mediated Regulation of Golgi Organization Is through the Direct Activation of Protein Kinase D
Colin Jamora,Norma Yamanouye,Johan Van Lint,John Laudenslager,John Laudenslager,Jackie R. Vandenheede,D. John Faulkner,Vivek Malhotra +7 more
TL;DR: The results demonstrate that Gβγ directly activates PKD by interacting with its PH domain, suggesting a possible mechanism by which the direct interaction of G βγ with PKD regulates the dynamics of Golgi membranes and protein secretion.
Journal ArticleDOI
On the role of calcium as second messenger in liver for the hormonally induced activation of glycogen phosphorylase
TL;DR: The data are interpreted in favour of a role of calcium as the second messenger in liver for the three cyclic AMP-independent glycogenolytic hormones and as an additional messenger for glucagon which, via cyclicAMP, will make calcium available to the cytoplasm either from extracellular or from intracellular pools.