J
Jackson B. Gibbs
Researcher at United States Military Academy
Publications - 117
Citations - 12704
Jackson B. Gibbs is an academic researcher from United States Military Academy. The author has contributed to research in topics: Farnesyl Protein Transferase & Farnesyltransferase. The author has an hindex of 55, co-authored 117 publications receiving 12547 citations. Previous affiliations of Jackson B. Gibbs include Merck & Co. & Duke University.
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Journal ArticleDOI
Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic.
Journal Article
A Peptidomimetic Inhibitor of Farnesyl:Protein Transferase Blocks the Anchorage-dependent and -independent Growth of Human Tumor Cell Lines
Laura Sepp-Lorenzino,Zhenping Ma,Elaine Rands,Nancy E. Kohl,Jackson B. Gibbs,Oliff Allen I,Neal Rosen +6 more
TL;DR: FPTase inhibitors are potent antitumor agents with activity against many types of human cancer cell lines, including those with wild-type ras, and resistance in some cells is associated with the presence of Ras-independent pathways for mitogen-activated protein kinase activation by tyrosine kinases.
Journal ArticleDOI
PDGF induction of tyrosine phosphorylation of GTPase activating protein.
Christopher J. Molloy,Donald P. Bottaro,Timothy P. Fleming,Mark S. Marshall,Jackson B. Gibbs,Stuart A. Aaronson +5 more
TL;DR: In intact quiescent fibroblasts, both AA and BB homodimers of PDGF rapidly induce tyrosine phosphorylation of GAP under conditions in which insulin and basic fibroblast growth factor are ineffective.
Journal ArticleDOI
The potential of farnesyltransferase inhibitors as cancer chemotherapeutics.
Jackson B. Gibbs,Oliff Allen I +1 more
TL;DR: Inhibitors of the enzyme that catalyzes Ras farnesylation,farnesyl-protein transferase (FPTase), have been developed and are among the first small molecule compounds designed from studies of oncogenes that might serve as novel cancer chemotherapeutics.