J
Jackson B. Gibbs
Researcher at United States Military Academy
Publications - 117
Citations - 12704
Jackson B. Gibbs is an academic researcher from United States Military Academy. The author has contributed to research in topics: Farnesyl Protein Transferase & Farnesyltransferase. The author has an hindex of 55, co-authored 117 publications receiving 12547 citations. Previous affiliations of Jackson B. Gibbs include Merck & Co. & Duke University.
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Journal ArticleDOI
Kinase-Deficient Pak1 Mutants Inhibit Ras Transformation of Rat-1 Fibroblasts
Yi Tang,Zunxuan Chen,Diane M. Ambrose,Jianhua Liu,Jackson B. Gibbs,Jonathan Chernoff,Jeffrey Field +6 more
TL;DR: It is shown that expression of a catalytically inactive mutant Pak, Pak1(R299), inhibits Ras transformation of Rat-1 fibroblasts but not of NIH 3T3 cells, suggesting that Pak1 interacts with components essential for Ras transformation and that inhibition can be uncoupled from JNK but not ERK signaling.
Mutant ras-encoded proteins with altered nucleotide binding exert dominant biological effects (binding site/G protein/mutagenesis/mammalian transformation/yeast lethality)
Irving S. Sigal,Jackson B. Gibbs,S Jill,Gretchen L. Temeles,Bohdan S. Wolanski,Susan H. Socher,Edward M. Scolnick +6 more
TL;DR: It is reported that residues Lys-16 and Asp-119 play critical roles in the guanine nucleotide binding and, consequently, the biological function of the Ha-ras-encoded protein (Ha) and a structural model for the GDP/GTP-binding site of Ha is proposed.
Journal ArticleDOI
Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase.
Michael D. Schaber,M. B. O'hara,Victor M. Garsky,Scott D. Mosser,James D. Bergstrom,S L Moores,Mark S. Marshall,Paul A. Friedman,Richard A. F. Dixon,Jackson B. Gibbs +9 more
TL;DR: In this article, Farnesyl-PPi was used as a precursor and Escherichia coli-expressed Ras was radiolabeled upon incubation with the cytosolic fraction of bovine brain.
Journal ArticleDOI
A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis
Rebecca E. Barrington,Mark A. Subler,Elaine Rands,Charles A. Omer,Patricia Miller,Jeffrey E. Hundley,Koester Sk,Dean A. Troyer,David J. Bearss,Michael W. Conner,Jackson B. Gibbs,Kelly Hamilton,Kenneth S. Koblan,Scott D. Mosser,Timothy J. O'Neill,Michael D. Schaber,Edith T. Senderak,Jolene J. Windle,Oliff Allen I,Nancy E. Kohl +19 more
TL;DR: It is demonstrated that a farnesyltransferase inhibitor can induce regression of v-Ha-ras-bearing tumors by multiple mechanisms, including the activation of a suppressed apoptotic pathway, which is largely p53 independent, or by cell cycle alterations, depending upon the presence of various other oncogenic genetic alterations.
Journal ArticleDOI
Yeast and mammalian ras proteins have conserved biochemical properties
TL;DR: It is reported here that the N-terminal domain of SC1 binds GTP and GDP and has a GTP hydrolytic activity that is reduced in the variants SC1 [Thr 66] and SC1[Leu 68] which are analogous to oncogenic Ha[Thr 59] and Ha[ Leu 61], respectively.