Jacob K. Sont

TL;DR: It is concluded that reducing AHR in conjunction with optimizing symptoms and lung function leads to more effective control of asthma while alleviating chronic airways inflammation, implying a role for the monitoring of AHR or other surrogate markers of inflammation in the long-term management of asthma.

TL;DR: Among patients with early diffuse cutaneous systemic sclerosis, HSCT was associated with increased treatment-related mortality in the first year after treatment, however, HCST conferred a significant long-term event-free survival benefit.

TL;DR: A role for TGF- b 1 is suggested in recruiting macrophages into the airway epithelium in COPD by immunohistochemistry and mRNA in situ hybridization in peripheral lung tissue of 14 current or ex-smokers with COPD and 14 without COPD.

TL;DR: The in situ protein and mRNA expression of monocyte chemoattractant protein 1 and of interleukin 8 are studied in tumour‐free peripheral lung tissue resected for lung cancer of current or ex‐smokers with COPD and without COPD suggest that MCP‐1 and CCR2 are involved in the recruitment of macrophages and mast cells into the airway epithelium in COPD.

TL;DR: Infiltration of inflammatory cells in the lamina propria of the airways seems to persist in asthmatic outpatients despite regular treatment with inhaled steroids, reflected by airway hyperresponsiveness to methacholine, but not by symptoms or lung function.