W
Willem E. Fibbe
Researcher at Leiden University Medical Center
Publications - 292
Citations - 27827
Willem E. Fibbe is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Transplantation & Stem cell. The author has an hindex of 73, co-authored 287 publications receiving 25923 citations. Previous affiliations of Willem E. Fibbe include Leiden University & Katholieke Universiteit Leuven.
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Journal ArticleDOI
Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study.
Katarina Le Blanc,Francesco Frassoni,Lynne M. Ball,Franco Locatelli,Helene Roelofs,Ian D. Lewis,Edoardo Lanino,Berit Sundberg,Maria Ester Bernardo,Mats Remberger,Giorgio Dini,R. Maarten Egeler,Andrea Bacigalupo,Willem E. Fibbe,Olle Ringdén +14 more
TL;DR: Infusion of mesenchymal stem cells expanded in vitro, irrespective of the donor, might be an effective therapy for patients with steroid-resistant, acute GVHD.
Journal ArticleDOI
Immunomodulatory properties of mesenchymal stromal cells.
Alma J. Nauta,Willem E. Fibbe +1 more
TL;DR: The aim of this review is to critically discuss the immunogenicity and immunomodulatory properties of MSCs, both in vitro and in vivo, the possible underlying mechanisms, the potential clinical use of M SCs as modulators of immune responses in vivo and to indicate clinical safety concerns and recommendations for future research.
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Isolation of Mesenchymal Stem Cells of Fetal or Maternal Origin from Human Placenta
Pieternella S. in `t Anker,Sicco A. Scherjon,Carin Kleijburg-van der Keur,Godelieve M.J.S. de Groot-Swings,Frans H.J. Claas,Willem E. Fibbe,Humphrey H.H. Kanhai +6 more
TL;DR: It is reported that second‐trimester amniotic fluid (AF) is an abundant source of fetal mesenchymal stem cells (MSCs), and different parts of the human placenta were studied for the presence of either fetal or maternal MSCs.
Journal ArticleDOI
Mesenchymal stromal cells: sensors and switchers of inflammation.
TL;DR: Current insights into the ways in which MSCs sense and control inflammation are outlined, highlighting the central role of macrophage polarization and progress toward clinical application is discussed.
Journal ArticleDOI
Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins
A.H. Schinkel,U. Mayer,Els Wagenaar,C. A. A. M. Mol,L. Van Deemter,J. J. M. Smit,M. A. Van Der Valk,A. C. Voordouw,Hergen Spits,O. van Tellingen,J. M. J. M. Zijlmans,Willem E. Fibbe,Piet Borst +12 more
TL;DR: Mdr1a/1b (-/-) mice should provide a useful model system to further test the pharmacological roles of the drug-transporting P-gps and to analyze the specificity and effectivity of P-gp-blocking drugs.