Jacqueline M. Stephens

TL;DR: It is established that calorie restriction and exercise-mediated weight loss in obese individuals with type 2 diabetes is associated with a reduction in adipose tissue expression of Nlrp3 as well as with decreased inflammation and improved insulin sensitivity, and that the NlrP3 inflammasome senses obesity-associated danger signals and contributes to obesity-induced inflammation and insulin resistance.

TL;DR: The insulin resistance of glucose transport in 3T3-L1 adipocytes exposed to TNF-α for 72-96 h results from a reduced amount in requisite proteins involved in insulin action, consistent with earlier studies indicating that T NF-α reduces the transcriptional activity of the GLUT4 gene in murine adipocytes, and reduced mRNA transcription of a number of relevant genes.

TL;DR: The lack of response to insulin appeared due to a suppression ofGLUT4 expression as well as a decreased intracellular content of GLUT1, which was judged to be regulated at least in part at the level of transcription.

TL;DR: It is established that ARTs have a restricted TCR-Vβ repertoire, and T cells contribute toward the complex proinflammatory microenvironment of adipose tissue in obesity.

TL;DR: Adropinregulated expression of hepatic lipogenic genes and adipose tissue peroxisome proliferator-activated receptor gamma, a major regulator of lipogenesis, may be a factor governing glucose and lipid homeostasis, which protects against hepatosteatosis and hyperinsulinemia associated with obesity.