J
Jacquelyn Freund
Researcher at New York University
Publications - 2
Citations - 310
Jacquelyn Freund is an academic researcher from New York University. The author has contributed to research in topics: Cyclin-dependent kinase 8 & Cyclin D. The author has an hindex of 2, co-authored 2 publications receiving 269 citations.
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Journal ArticleDOI
Therapeutic Targeting of the Cyclin D3:CDK4/6 Complex in T Cell Leukemia
Catherine M. Sawai,Jacquelyn Freund,Philmo Oh,Delphine Ndiaye-Lobry,Jamieson Bretz,Alexandros Strikoudis,Lali Genesca,Thomas Trimarchi,Michelle A. Kelliher,Marcus R. Clark,Jean Soulier,Selina Chen-Kiang,Iannis Aifantis +12 more
TL;DR: It is shown that only combined deletion of p27(Kip1) and retinoblastoma tumor suppressor (Rb) is sufficient to rescue the development of Ccnd3(-/-) thymocytes and a small molecule targeting the kinase function of cyclin D3:CDK4/6 inhibits both cell cycle entry in human T cell acute lymphoblastic leukemia (T-ALL) and disease progression in animal models of T-ALL.
Journal ArticleDOI
Notch pathway activation targets AML-initiating cell homeostasis and differentiation
Camille Lobry,Panagiotis Ntziachristos,Delphine Ndiaye-Lobry,Philmo Oh,Luisa Cimmino,Nan Zhu,Elisa Araldi,Wenhuo Hu,Jacquelyn Freund,Omar Abdel-Wahab,Sherif Ibrahim,Dimitris Skokos,Scott A. Armstrong,Ross L. Levine,Christopher Y. Park,Iannis Aifantis +15 more
TL;DR: Notch behaves as a tumor suppressor in AML, and Notch activation induces cell cycle arrest, differentiation, and apoptosis of AML-initiating cells.