C
Catherine M. Sawai
Researcher at University of Bordeaux
Publications - 16
Citations - 1964
Catherine M. Sawai is an academic researcher from University of Bordeaux. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 11, co-authored 14 publications receiving 1480 citations. Previous affiliations of Catherine M. Sawai include Columbia University Medical Center & University of Chicago.
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Journal ArticleDOI
γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
Pedro J. Real,Valeria Tosello,Teresa Palomero,Teresa Palomero,Mireia Castillo,Eva Hernando,Elisa de Stanchina,Maria Luisa Sulis,Maria Luisa Sulis,Kelly Barnes,Catherine M. Sawai,Irene Homminga,Jules P.P. Meijerink,Iannis Aifantis,Giuseppe Basso,Carlos Cordon-Cardo,Weiyun Z. Ai,Adolfo A. Ferrando,Adolfo A. Ferrando +18 more
TL;DR: It is shown that combination therapy with GSIs plus glucocorticoids can improve the antileukemic effects of GSIs and reduce their gut toxicity in vivo and support a role for glucocORTicoid-resistant T-ALL.
Journal ArticleDOI
Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals.
Catherine M. Sawai,Sonja Babovic,Samik Upadhaya,Samik Upadhaya,David J.H.F. Knapp,Yonit Lavin,Colleen M. Lau,Anton Goloborodko,Jue Feng,Joji Fujisaki,Lei Ding,Leonid A. Mirny,Miriam Merad,Connie J. Eaves,Boris Reizis,Boris Reizis +15 more
TL;DR: The authors showed that transgene-expressing HSCs gave rise to other phenotypic HSC cells, confirming their top position in the differentiation hierarchy, but not to B-1a cells or tissue macrophages.
Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals
Catherine M. Sawai,Sonja Babovic,Samik Upadhaya,David J.H.F. Knapp,Yonit Lavin,Colleen M. Lau,Jue Feng,Joji Fujisaki,Lei Ding,Miriam Merad,Connie J. Eaves,Boris Reizis,Anton Goloborodko,Leonid A. Mirny +13 more
TL;DR: It is shown that transgene expression in a fraction of HSCs that maintained reconstituting activity during serial transplantations gave rise to other phenotypic HSCS, confirming their top position in the differentiation hierarchy.
Journal ArticleDOI
Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling
Kristen Johnson,Tamar Hashimshony,Catherine M. Sawai,Catherine M. Sawai,Jagan M. R. Pongubala,Jagan M. R. Pongubala,Jane A. Skok,Jane A. Skok,Iannis Aifantis,Iannis Aifantis,Harinder Singh,Harinder Singh +11 more
TL;DR: Using Irf4-/-Irf8-/- pre-B cells, it is demonstrated that two pathways converge to synergistically drive light-chain rearrangement, but not simply as a consequence of cell-cycle exit.
Journal ArticleDOI
Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells.
Maria Casanova-Acebes,Erica Dalla,Andrew Leader,Jessica LeBerichel,Jovan Nikolic,Blanca M. Morales,Markus Brown,Christie Chang,Leanna Troncoso,Steven T. Chen,Ana Sastre-Perona,Matthew D. Park,Alexandra Tabachnikova,Maxime Dhainaut,Pauline Hamon,Barbara Maier,Catherine M. Sawai,Esperanza Agulló-Pascual,Markus Schober,Brian D. Brown,Boris Reizis,Thomas U. Marron,Ephraim Kenigsberg,Christine Moussion,Philippe Benaroch,Julio A. Aguirre-Ghiso,Miriam Merad +26 more
TL;DR: In this article, single-cell RNA sequencing and imaging of macrophages in human non-small cell lung cancer and in a mouse model of lung adenocarcinoma was performed.