J
Jacques Amar
Researcher at French Institute of Health and Medical Research
Publications - 111
Citations - 11404
Jacques Amar is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Blood pressure & Population. The author has an hindex of 34, co-authored 108 publications receiving 9854 citations. Previous affiliations of Jacques Amar include University of Toulouse & Paul Sabatier University.
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Journal ArticleDOI
Metabolic endotoxemia initiates obesity and insulin resistance
Patrice D. Cani,Jacques Amar,Miguel A. Iglesias,Marjorie Poggi,Claude Knauf,Delphine Bastelica,Audrey M. Neyrinck,Francesca Fava,Kieran Tuohy,Chantal Chabo,Aurélie Waget,Evelyne Delmée,Béatrice Cousin,Thierry Sulpice,Bernard Chamontin,Jean Ferrières,Jean-François Tanti,Glenn R. Gibson,Louis Casteilla,Nathalie M. Delzenne,Marie-Christine Alessi,Rémy Burcelin +21 more
TL;DR: It is concluded that the LPS/CD14 system sets the tone of insulin sensitivity and the onset of diabetes and obesity and lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases.
Journal ArticleDOI
Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment
Jacques Amar,Chantal Chabo,Aurélie Waget,Pascale Klopp,Christelle Vachoux,Luis G. Bermúdez-Humarán,Natalia F. Smirnova,Mathieu Bergé,Mathieu Bergé,Thierry Sulpice,Sampo J. Lahtinen,Arthur C. Ouwehand,Philippe Langella,Nina Rautonen,Philippe J. Sansonetti,Rémy Burcelin +15 more
TL;DR: It is demonstrated that the early onset of HFD‐induced hyperglycemia is characterized by an increased bacterial translocation from intestine towards tissues, fuelling a continuous metabolic bacteremia, which could represent new therapeutic targets.
Journal ArticleDOI
Energy intake is associated with endotoxemia in apparently healthy men
Jacques Amar,Rémy Burcelin,Jean Bernard Ruidavets,Patrice D. Cani,Josette Fauvel,Marie-Christine Alessi,Bernard Chamontin,Jean Ferrières +7 more
TL;DR: Experimental data suggest that fat was more efficient in transporting bacterial LPS from the gut lumen into the bloodstream, and a link between food intake and plasma LPS was found in this large sample of healthy men.
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Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota
Matteo Serino,Elodie Luche,Sandra Grès,Audrey Baylac,Mathieu Bergé,Claire Cenac,Aurélie Waget,Pascale Klopp,Jason S. Iacovoni,Christophe Klopp,Jérôme Mariette,Olivier Bouchez,Jérôme Lluch,Françoise Ouarné,Pierre Monsan,Philippe Valet,Christine Roques,Jacques Amar,Anne Bouloumié,Vassilia Theodorou,Rémy Burcelin +20 more
TL;DR: The HFD-D gut microbial profile was associated with increased gut permeability linked to increased endotoxaemia and to a dramatic increase in cell number in the stroma vascular fraction from visceral white adipose tissue.
Journal ArticleDOI
Comprehensive description of blood microbiome from healthy donors assessed by 16S targeted metagenomic sequencing.
Sandrine Païssé,Carine Valle,Florence Servant,Michael Courtney,Rémy Burcelin,Jacques Amar,Benjamin Lelouvier +6 more
TL;DR: The objective of this study was to provide a comprehensive description of the microbiome present in different fractions of the blood of healthy individuals.