D
Deniz Toksoz
Researcher at Tufts Medical Center
Publications - 52
Citations - 3391
Deniz Toksoz is an academic researcher from Tufts Medical Center. The author has contributed to research in topics: Guanine nucleotide exchange factor & RHOA. The author has an hindex of 30, co-authored 49 publications receiving 3273 citations. Previous affiliations of Deniz Toksoz include Scripps Research Institute & University of California, Los Angeles.
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Journal ArticleDOI
Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture
Yasuhisa Matsui,Deniz Toksoz,Satomi Nishikawa,Shin-Ichi Nishikawa,David A. Williams,Krisztina M. Zsebo,Brigid L.M. Hogan +6 more
TL;DR: It is shown that leukaemia inhibitory factor (also known as differentiation inhibitory activity)17,18, a factor secreted by STO fibroblasts, can stimulate proliferation of primordial germ cells in vitro.
Journal ArticleDOI
Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia.
Johannes L. Bos,Deniz Toksoz,Christopher J. Marshall,Matty Verlaan de Vries,G. H. Veeneman,Alex J. van der Eb,Jacques H. van Boom,Johannes W.G. Janssen,Ada C. M. Steenvoorden +8 more
TL;DR: DNAs from four out of five patients with acute myeloid leukaemia tested by an in vivo selection assay in nude mice using transfected mouse NIH 3T3 cells were found to contain an activated N-ras oncogene.
Journal ArticleDOI
Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor.
Deniz Toksoz,K M Zsebo,K A Smith,S Hu,David W. Brankow,S V Suggs,F H Martin,David A. Williams +7 more
TL;DR: It is reported that stable stromal cell transfectants can differentially process the two forms of human SCF protein product, and both soluble SCF and membrane-bound SCF are active in increasing the number of human progenitor cells in the context of stromAL cell cultures, although in a qualitatively different manner.
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Direct Involvement of the Small GTP-binding Protein Rho in lbc Oncogene Function
TL;DR: Results strongly indicate that the lbc oncogene encodes a specific guanine nucleotide exchange factor for Rho and causes cellular transformation through activation of the Rho signaling pathway.
Journal ArticleDOI
Involvement of the Small GTPase Rho in Integrin-mediated Activation of Mitogen-activated Protein Kinase
TL;DR: Results show that Rho is involved in the integrin-dependent activation of MAP kinase, and enhanced and partially mimicked activation of Erk2 by plating on fibronectin.