Jae Hong Seol

TL;DR: Removal of Drosophila PINK1 homologue function results in male sterility, apoptotic muscle degeneration, defects in mitochondrial morphology and increased sensitivity to multiple stresses including oxidative stress, which underscores the importance of mitochondrial dysfunction as a central mechanism of Parkinson's disease pathogenesis.

TL;DR: A mutation is identified, net1-1, that bypasses the lethality of tem1 delta and is a key component of a multifunctional complex, denoted RENT (for regulator of nucleolar silencing and telophase), that also contains Cdc14 and the silencing regulator Sir2.

TL;DR: It is concluded that Cdc53/Hrt1 comprise a highly conserved module that serves as the functional core of a broad variety of heteromeric ubiquitin ligases.

TL;DR: The identification of 16 Skp1 and Cdc53-associated proteins in budding yeast and the show that RAVE promotes glucose-triggered assembly of the V-ATPase holoenzyme provide a distinct view of the interactions that link proteins into a comprehensive cellular network.

TL;DR: A new type of ATP-dependent protease is isolated from Escherichia coli that encodes two proteins: HslV, a 19-kDa protein similar to proteasome beta subunits, and HslU, a 50- kDa protein related to the ATPase ClpX, which appears to form a complex in which ATP hydrolysis by HSlU is essential for peptide hydrolyisation by the proteasomesome-like component HSlV.