J
Jae Hong Seol
Researcher at Seoul National University
Publications - 69
Citations - 6286
Jae Hong Seol is an academic researcher from Seoul National University. The author has contributed to research in topics: HslVU & Ubiquitin ligase. The author has an hindex of 35, co-authored 69 publications receiving 5860 citations. Previous affiliations of Jae Hong Seol include UPRRP College of Natural Sciences & University of Tokushima.
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Journal ArticleDOI
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin.
Ira E. Clark,Mark W. Dodson,Changan Jiang,Joseph Cao,Jun R. Huh,Jae Hong Seol,Soon Ji Yoo,Bruce A. Hay,Ming Guo +8 more
TL;DR: Removal of Drosophila PINK1 homologue function results in male sterility, apoptotic muscle degeneration, defects in mitochondrial morphology and increased sensitivity to multiple stresses including oxidative stress, which underscores the importance of mitochondrial dysfunction as a central mechanism of Parkinson's disease pathogenesis.
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Exit from Mitosis Is Triggered by Tem1-Dependent Release of the Protein Phosphatase Cdc14 from Nucleolar RENT Complex
Wenying Shou,Jae Hong Seol,Anna Shevchenko,Christopher Baskerville,Danesh Moazed,Z.W.Susan Chen,Joanne W. Jang,Andrej Shevchenko,Harry Charbonneau,Raymond J. Deshaies +9 more
TL;DR: A mutation is identified, net1-1, that bypasses the lethality of tem1 delta and is a key component of a multifunctional complex, denoted RENT (for regulator of nucleolar silencing and telophase), that also contains Cdc14 and the silencing regulator Sir2.
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Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34.
Jae Hong Seol,R. M. Renny Feldman,Wolfgang Zachariae,Andrej Shevchenko,Craig C. Correll,Svetlana Lyapina,Y. Chi,Marta Galova,Jonathan A. Claypool,Suzanne Sandmeyer,Kim Nasmyth,Raymond J. Deshaies +11 more
TL;DR: It is concluded that Cdc53/Hrt1 comprise a highly conserved module that serves as the functional core of a broad variety of heteromeric ubiquitin ligases.
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Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly
TL;DR: The identification of 16 Skp1 and Cdc53-associated proteins in budding yeast and the show that RAVE promotes glucose-triggered assembly of the V-ATPase holoenzyme provide a distinct view of the interactions that link proteins into a comprehensive cellular network.
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Hslv-hslu : a novel atp-dependent protease complex in escherichia coli related to the eukaryotic proteasome
Markus Rohrwild,Olivier Coux,Haixia Huang,Richard P. Moerschell,Soon Ji Yoo,Jae Hong Seol,Chin Ha Chung,Alfred L. Goldberg +7 more
TL;DR: A new type of ATP-dependent protease is isolated from Escherichia coli that encodes two proteins: HslV, a 19-kDa protein similar to proteasome beta subunits, and HslU, a 50- kDa protein related to the ATPase ClpX, which appears to form a complex in which ATP hydrolysis by HSlU is essential for peptide hydrolyisation by the proteasomesome-like component HSlV.