Jae-Hyun Park

TL;DR: Live imaging of chemotherapy-treated mouse mammary carcinomas allowed us to follow drug distribution, cell death, and tumor-stroma interactions, and associations between vascular leakage and response to doxorubicin, showing that the microenvironment contributes critically to drug response via regulation of vascular permeability and innate immune cell infiltration.

TL;DR: Midkine (MDK), a heparin-binding growth factor, was overexpressed in all drug-resistant cell lines, strongly suggesting that MDK might contribute to multidrug resistance in gastric cancer cells.

TL;DR: It is suggested that PBK/TOPK is the cancer/testis antigen and its kinase function is likely to be related to its oncogenic activity, and it is suggested to be a promising molecular target for breast cancer therapy.

TL;DR: The findings suggest that the kinase activity of MELK is likely to affect mammary carcinogenesis through inhibition of the pro-apoptotic function of Bcl-GL.

TL;DR: T cell receptor repertoire analysis using next‐generation sequencing technologies and identified infiltration of clonally expanded T cell populations in the skeletal muscle after nivolumab treatment, implying a very strong T cell immune response against muscular cells.