Elizabeth S. Nakasone

TL;DR: Understanding the complex ways in which cancer cells interact with their surroundings, both locally in the tumor organ and systemically in the body as a whole, has implications for effective cancer prevention and therapy.

TL;DR: The data suggest that induction of NETs by cancer cells is a previously unidentified metastasis-promoting tumor-host interaction and a potential therapeutic target, and treatment with NET-digesting, DNase I–coated nanoparticles markedly reduced lung metastases in mice.

TL;DR: Live imaging of chemotherapy-treated mouse mammary carcinomas allowed us to follow drug distribution, cell death, and tumor-stroma interactions, and associations between vascular leakage and response to doxorubicin, showing that the microenvironment contributes critically to drug response via regulation of vascular permeability and innate immune cell infiltration.

TL;DR: Future directions include increased electronic health record integration for direct data ingestion, expansion to additional domestic and international sites, more intentional patient involvement, and granular analyses of still-unanswered questions related to cancer subtypes and treatments.

TL;DR: A method for using spinning disk confocal microscopy of live, anesthetized mice to directly observe drug distribution, cancer cell responses and changes in tumor-stroma interactions following administration of systemic therapy in breast cancer models is provided.