J
Jagu Subhashini
Researcher at University of Hyderabad
Publications - 11
Citations - 754
Jagu Subhashini is an academic researcher from University of Hyderabad. The author has contributed to research in topics: Apoptosis & Cytochrome c. The author has an hindex of 7, co-authored 7 publications receiving 709 citations. Previous affiliations of Jagu Subhashini include Johns Hopkins University.
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Journal ArticleDOI
Molecular mechanisms in C-Phycocyanin induced apoptosis in human chronic myeloid leukemia cell line-K562.
Jagu Subhashini,Suraneni V.K. Mahipal,Madhava C. Reddy,Metukuri Mallikarjuna Reddy,Aparna Rachamallu,Pallu Reddanna +5 more
TL;DR: It is demonstrated that C-PC induces apoptosis in K562 cells by cytochrome c release from mitochondria into the cytosol, PARP cleavage and down regulation of Bcl-2.
Journal ArticleDOI
C-Phycocyanin, a selective cyclooxygenase-2 inhibitor, induces apoptosis in lipopolysaccharide-stimulated RAW 264.7 macrophages.
Madhava C. Reddy,Jagu Subhashini,Suraneni V.K. Mahipal,Vadiraja B. Bhat,P Srinivas Reddy,G. Kiranmai,K.M. Madyastha,Pallu Reddanna +7 more
TL;DR: This C-PC induced apoptosis in RAW 264.7 cells appears to be mediated by the release of cytochrome c from mitochondria and independent of Bcl-2 expression, and may be due to reduced PGE(2) levels as a result of COX-2 inhibition.
Journal ArticleDOI
Bacterial lipopolysaccharide-induced oxidative stress in the impairment of steroidogenesis and spermatogenesis in rats.
M Mallikarjuna Reddy,Suraneni V.K. Mahipal,Jagu Subhashini,Madhava C. Reddy,Karnati R. Roy,Gorla V. Reddy,Pingili R.K. Reddy,Pallu Reddanna +7 more
TL;DR: Data from an LPS rat model are consistent with oxidative stress as a major causal factor in altered steroidogenesis, spermatogenesis, and perhaps male infertility during endotoxin-induced acute inflammation.
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Anti-proliferative and apoptotic effects of celecoxib on human chronic myeloid leukemia in vitro.
TL;DR: Celecoxib potentiates apoptosis as shown by MTT assay, cytochrome c leakage, PARP cleavage, DNA fragmentation, Bcl-2 downregulation and possibly by inhibiting NF-kB activation.
Journal ArticleDOI
Effect of 15-lipoxygenase metabolites, 15-(S)-HPETE and 15-(S)-HETE on chronic myelogenous leukemia cell line K-562: reactive oxygen species (ROS) mediate caspase-dependent apoptosis.
Suraneni V.K. Mahipal,Jagu Subhashini,Madhava C. Reddy,Metukuri Mallikarjuna Reddy,Kotha Anilkumar,Karnati R. Roy,Gorla V. Reddy,Pallu Reddanna +7 more
TL;DR: A flow cytometry based DCFH-DA analysis and inhibitory studies with DPI revealed that NADPH oxidase-mediated generation of ROS is responsible for caspase-3 activation and subsequent induction of apoptosis in the K-562 cell line.