http://experimentationlab.berkeley.edu/sites/default/files/AFMImages/butt_AFM.pdf

Force measurements with the atomic force microscope: Technique, interpretation and applications

https://cyberleninka.org/article/n/148766.pdf

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

/pdf/controlling-tgf-b-signaling-1bmt23qt86.pdf

Controlling TGF-β signaling

Cell proliferation, differentiation and death are controlled by a multitude of cell-cell signals, and loss of this control has devastating consequences Prominent among these regulatory signals is the transforming growth factor-beta (TGF-beta) family of cytokines, which can trigger a bewildering diversity of responses, depending on the genetic makeup and environment of the target cell What are the networks of cell-specific molecules that mould the TGF-beta response to each cell's needs?

How cells read TGF-beta signals.

http://bio.gsnu.ac.kr/research/SUMO/general/Ub_BBA_2004.pdf

Ubiquitin: structures, functions, mechanisms.

Single molecule force spectroscopy of spectrin repeats: low unfolding forces in helix bundles.

In the chick embryo, left-right asymmetric patterns of gene expression in the lateral plate mesoderm are initiated by signals located in and around Hensen's node. Here we show that Caronte (Car), a secreted protein encoded by a member of the Cerberus/Dan gene family, mediates the Sonic hedgehog (Shh)-dependent induction of left-specific genes in the lateral plate mesoderm. Car is induced by Shh and repressed by fibroblast growth factor-8 (FGF-8). Car activates the expression of Nodal by antagonizing a repressive activity of bone morphogenic proteins (BMPs). Our results define a complex network of antagonistic molecular interactions between Activin, FGF-8, Lefty-1, Nodal, BMPs and Car that cooperate to control left-right asymmetry in the chick embryo.

The novel Cer-like protein Caronte mediates the establishment of embryonic left–right asymmetry

Solution structure of the spectrin repeat: a left-handed antiparallel triple-helical coiled-coil.

Structure of the PHD zinc finger from human Williams-Beuren syndrome transcription factor.

The archetype of MAPK cascade activation is somewhat challenged by the most recent discovery of unexpected phosphorylation patterns, alternative activation mechanisms and sub-cellular localization, in various members of this protein kinase family. In particular, activation by autophosphorylation pathways has now been described for the three best understood MAPK subgroups: ERK1/2; JNK1/2 and p38 alpha/beta. Also, a form of dosage compensation between homologs has been shown to occur in the case of ERK1/2 and JNK1/2. In this paper we summarize the MAPK activation pathway, with an emphasis on non-canonical examples. We use this information to propose a model for MAPK signal transduction that considers a cross-talk between MAPKs with different activation loop sequence motifs and unique C-terminal extensions. We highlight the occurrence of non-canonical substrate specificity during MAPK auto-activation, in strong connection with MAPK homo- and hetero-dimerization events.

Jaime Pascual

Papers

Single molecule force spectroscopy of spectrin repeats: low unfolding forces in helix bundles.

The novel Cer-like protein Caronte mediates the establishment of embryonic left–right asymmetry

Solution structure of the spectrin repeat: a left-handed antiparallel triple-helical coiled-coil.

Structure of the PHD zinc finger from human Williams-Beuren syndrome transcription factor.

Canonical and alternative MAPK signaling.