J
Jaimee R. Compton
Researcher at United States Naval Research Laboratory
Publications - 26
Citations - 304
Jaimee R. Compton is an academic researcher from United States Naval Research Laboratory. The author has contributed to research in topics: Protease & Venezuelan equine encephalitis virus. The author has an hindex of 9, co-authored 21 publications receiving 217 citations. Previous affiliations of Jaimee R. Compton include United States Department of the Army & MedImmune.
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Journal ArticleDOI
Melanin Produced by the Fast-Growing Marine Bacterium Vibrio natriegens through Heterologous Biosynthesis: Characterization and Application.
Zheng Wang,Tanya Tschirhart,Zachary Schultzhaus,Erin E. Kelly,Amy Chen,Eunkeu Oh,Okhil K. Nag,Evan R. Glaser,Eunkyoung Kim,Pamela F. Lloyd,Paul T. Charles,Weiyao Li,Dagmar H. Leary,Jaimee R. Compton,Daniel A. Phillips,Ali Dhinojwala,Gregory F. Payne,Gary J. Vora +17 more
TL;DR: This study engineered the extremely fast-growing bacterium V. natriegens to synthesize melanin nanoparticles by expressing a heterologous tyrosinase gene with inducible promoters and demonstrated that melanin production was much faster than in previously reported heterologicous systems.
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Probing the donor and acceptor substrate specificity of the γ-glutamyl transpeptidase.
Xin Hu,Patricia M. Legler,Ilja V. Khavrutskii,Angelo Scorpio,Jaimee R. Compton,Kelly L. Robertson,Arthur M. Friedlander,Anders Wallqvist +7 more
TL;DR: Docking and MD simulations point toward key residues that contribute to inhibitor and acceptor substrate binding, providing a guide to designing novel and specific GGT inhibitors.
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Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease
Xin Hu,Jaimee R. Compton,Dagmar H. Leary,Mark A. Olson,Michael S. Lee,Jonah Cheung,Wenjuan Ye,Mark Ferrer,Noel Southall,Ajit Jadhav,Elaine M. Morazzani,Pamela J. Glass,Juan J. Marugan,Patricia M. Legler +13 more
TL;DR: The structures and identified active site residues may facilitate the discovery of protease inhibitors with antiviral activity and help understand the roles of conserved residues in catalysis.
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Introduction of a disulfide bond leads to stabilization and crystallization of a ricin immunogen
Jaimee R. Compton,Patricia M. Legler,Benjamin V. Clingan,Mark A. Olson,Charles B. Millard,Charles B. Millard +5 more
TL;DR: The importance of RTA loop 34 to 55 as a nucleus for unfolding and aggregation, and draw conclusions for ongoing structure‐based minimalist design of R TA‐based immunogens, are discussed.
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3-Substituted Indole Inhibitors Against Francisella tularensis FabI Identified by Structure-Based Virtual Screening
Xin Hu,Jaimee R. Compton,Mohamed Diwan M. AbdulHameed,Charles L. Marchand,Kelly L. Robertson,Dagmar H. Leary,Ajit Jadhav,Jeremy R. Hershfield,Anders Wallqvist,Arthur M. Friedlander,Patricia M. Legler +10 more
TL;DR: Binding interaction analysis in conjunction with site-directed mutagenesis revealed key residues and elements that contribute to inhibitor binding and species specificity andutation of Arg-96, a poorly conserved residue opposite the loop, was unexpectedly found to enhance inhibitor binding in the R96G and R96M variants.