J
James B. McMahon
Researcher at National Institutes of Health
Publications - 158
Citations - 17953
James B. McMahon is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Virus & Griffithsin. The author has an hindex of 49, co-authored 158 publications receiving 16837 citations. Previous affiliations of James B. McMahon include Purdue University & McGill University.
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Journal ArticleDOI
New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening
Philip Skehan,Ritsa Storeng,Dominic A. Scudiero,Anne Monks,James B. McMahon,David T. Vistica,Jonathan T. Warren,Heidi R. Bokesch,Susan Kenney,Michael R. Boyd +9 more
TL;DR: The SRB assay provides a sensitive measure of drug-induced cytotoxicity, is useful in quantitating clonogenicity, and is well suited to high-volume, automated drug screening.
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The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum.
Yoel Kashman,Kirk R. Gustafson,Richard W. Fuller,John H. Cardellina,James B. McMahon,Michael J. Currens,Robert W. Buckheit,Stephen H. Hughes,Gordon M. Cragg,Michael R. Boyd +9 more
TL;DR: Calanolide A was active not only against the AZT-resistant G-9106 strain of HIV-1 but also against the pyridinone-resistant A17 strain, which was of particular interest since the A17 virus is highly resistant to previously known HIV- 1 specific, non-nucleoside RT inhibitors.
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Initial studies on the cellular pharmacology of 2′,3′-dideoxycytidine, an inhibitor of HTLV-III infectivity
David A. Cooney,Maha Dalal,Hiroaki Mitsuya,James B. McMahon,Mohan Nadkarni,Jan Balzarini,Samuel Broder,David G. Johns +7 more
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Circulins A and B. Novel human immunodeficiency virus (HIV)-inhibitory macrocyclic peptides from the tropical tree Chassalia parvifolia.
Kirk R. Gustafson,Raymond C. Sowder,Louis E. Henderson,Ian Parsons,Yoel Kashman,John H. Cardellina,James B. McMahon,Robert W. Buckheit,Lewis K. Pannell,Michael R. Boyd +9 more
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The guttiferones, HIV-inhibitory benzophenones from Symphonia globulifera, Garcinia livingstonei, Garcinia ovalifolia and Clusia rosea
Kirk R. Gustafson,John W. Blunt,Murray H. G. Munro,Richard W. Fuller,Tawnya C. McKee,John H. Cardellina,James B. McMahon,Gordon M. Cragg,Michael R. Boyd +8 more
TL;DR: In this article, a series of new polyisoprenylated benzophenone derivatives named guttiferones A-E (1, 2, 3, 4, 5) were found to inhibit the cytophatic effects of in vitro HIV infection.