D
David G. Johns
Researcher at National Institutes of Health
Publications - 173
Citations - 10912
David G. Johns is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Continuous Plankton Recorder & Climate change. The author has an hindex of 53, co-authored 165 publications receiving 10108 citations. Previous affiliations of David G. Johns include Rega Institute for Medical Research.
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Journal ArticleDOI
Trophic level asynchrony in rates of phenological change for marine, freshwater and terrestrial environments
Stephen J. Thackeray,Tim H. Sparks,Morten Frederiksen,Sarah J. Burthe,P. J. Bacon,James R. Bell,Marc S. Botham,Tom Brereton,Paul W. Bright,Laurence Carvalho,Tim H. Clutton-Brock,Alistair Dawson,Martin Edwards,J. Malcolm Elliott,Richard Harrington,David G. Johns,Ian D. Jones,James T. Jones,David I. Leech,David B. Roy,W. Andy Scott,Matt Smith,Richard J. Smithers,Ian J. Winfield,Sarah Wanless +24 more
TL;DR: In this article, the authors present a standardized assessment of 25 532 rates of phenological change for 726 UK terrestrial, freshwater and marine taxa and trophic levels and show that the majority of spring and summer events have advanced, and more rapidly than previously documented.
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Phenological sensitivity to climate across taxa and trophic levels
Stephen J. Thackeray,Peter A. Henrys,Deborah Hemming,James R. Bell,Marc S. Botham,Sarah J. Burthe,Pierre Hélaouët,David G. Johns,Ian D. Jones,David I. Leech,Eleanor B. Mackay,Dario Massimino,S. Atkinson,P. J. Bacon,Tom Brereton,Laurence Carvalho,Tim H. Clutton-Brock,Callan Duck,Martin Edwards,J. Malcolm Elliott,Stephen J. G. Hall,Richard Harrington,James W. Pearce-Higgins,Toke T. Høye,Loeske E. B. Kruuk,Loeske E. B. Kruuk,Josephine M. Pemberton,Tim H. Sparks,Paul M. Thompson,Ian R. White,Ian J. Winfield,Sarah Wanless +31 more
TL;DR: A Climate Sensitivity Profile approach is applied to 10,003 terrestrial and aquatic phenological data sets, spatially matched to temperature and precipitation data, to quantify variation in climate sensitivity and detected systematic variation in the direction and magnitude of phenological climate sensitivity.
Journal ArticleDOI
In vivo activity against HIV and favorable toxicity profile of 2',3'-dideoxyinosine
Robert Yarchoan,Hiroaki Mitsuya,Rose V. Thomas,James M. Pluda,Neil R. Hartman,Carlo Federico Perno,Kathy S. Marczyk,Jean-Pierre Allain,David G. Johns,Samuel Broder +9 more
TL;DR: Results suggest that serious short-term toxicity at therapeutic doses is not an inherent feature in the profile of agents with clinical anti-HIV activity and further controlled studies to define the safety and efficacy of this agent may be worth considering.
Journal ArticleDOI
Initial studies on the cellular pharmacology of 2′,3′-dideoxycytidine, an inhibitor of HTLV-III infectivity
David A. Cooney,Maha Dalal,Hiroaki Mitsuya,James B. McMahon,Mohan Nadkarni,Jan Balzarini,Samuel Broder,David G. Johns +7 more
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Replication of human immunodeficiency virus in monocytes. Granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by 3'-azido-2'3'-dideoxythymidine (AZT) and other dideoxynucleoside congeners of thymidine.
Carlo Federico Perno,Robert Yarchoan,David A. Cooney,Neil R. Hartman,D. S. A. Webb,Zhang Hao,Hiroaki Mitsuya,David G. Johns,Samuel Broder +8 more
TL;DR: It is suggested that GM-CSF increases HIV-1 replication in M/M, while at the same time enhancing the anti-HIV activity of AZT and related congeners in these cells.