J
James Finnigan
Researcher at Northumbria University
Publications - 18
Citations - 425
James Finnigan is an academic researcher from Northumbria University. The author has contributed to research in topics: Biocatalysis & Chemistry. The author has an hindex of 7, co-authored 12 publications receiving 211 citations.
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Journal ArticleDOI
nanoDSF as screening tool for enzyme libraries and biotechnology development.
Anders O. Magnusson,Anna Szekrenyi,Henk-Jan Joosten,James Finnigan,Simon J. Charnock,Wolf-Dieter Fessner +5 more
TL;DR: The use of nanoDSF for HTS of a phylogenetically diverse aldolase library is probed to identify novel thermostable enzymes from metagenomic sources and for the rapid measurements of variants from saturation mutagenesis.
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Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination.
James R. Marshall,Peiyuan Yao,Peiyuan Yao,Sarah L. Montgomery,James Finnigan,Thomas W. Thorpe,Ryan B. Palmer,Juan Mangas-Sanchez,Richard A. M. Duncan,Rachel S. Heath,Kirsty M. Graham,Darren J. Cook,Simon J. Charnock,Nicholas J. Turner +13 more
TL;DR: In this paper, the authors report the discovery of over 300 new imine reductases and the production of a large (384 enzymes) and sequence-diverse panel of imine reduction enzymes available for screening.
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Serum amyloid A induces interleukin‐6 in dermal fibroblasts via Toll‐like receptor 2, interleukin‐1 receptor‐associated kinase 4 and nuclear factor‐κB
Steven O'Reilly,Rachel Cant,Marzena Ciechomska,James Finnigan,Fiona Oakley,Sophie Hambleton,Jacob M. van Laar +6 more
TL;DR: The role of SAA in initiating interleukin‐6 (IL‐6) production in dermal fibroblasts and the role of TLR2 in this system are addressed and suggest that SAA is a danger signal that initiates IL‐6 signalling in systemic sclerosis via enhancedTLR2 signalling.
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Chemoenzymatic Synthesis of Substituted Azepanes by Sequential Biocatalytic Reduction and Organolithium-Mediated Rearrangement.
Wojciech Zawodny,Sarah L. Montgomery,James R. Marshall,James Finnigan,Nicholas J. Turner,Jonathan Clayden +5 more
TL;DR: The products are previously inaccessible enantioenriched 2,2-disubstituted azepanes and benzazepines and are described as configurationally stable benzyllithium intermediate.
Journal ArticleDOI
Role of toll-like receptors in systemic sclerosis
TL;DR: A better understanding of the mechanisms of TLR-mediated pathogenesis and therapies targeting individual TLRs, may provide a more specific approach of treating multi-systemic autoimmune diseases and suggest the TLR system as a new therapeutic target.