J
James J L Hodge
Researcher at University of Bristol
Publications - 57
Citations - 1809
James J L Hodge is an academic researcher from University of Bristol. The author has contributed to research in topics: Circadian rhythm & Circadian clock. The author has an hindex of 21, co-authored 52 publications receiving 1446 citations. Previous affiliations of James J L Hodge include Brandeis University & Queen Mary University of London.
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State-dependent judgement bias in Drosophila: evidence for evolutionarily primitive affective processes.
TL;DR: It is demonstrated that the fruit fly, Drosophila melanogaster, also exhibits state-dependent changes in cue interpretation, and use of this model organism's versatile experimental tool kit may facilitate elucidation of their neural and genetic basis.
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A third copy of the Down syndrome cell adhesion molecule (Dscam) causes synaptic and locomotor dysfunction in Drosophila.
TL;DR: DSCAM is identified as a candidate causative gene in DS that is sufficient to modify synaptic transmission and synaptic plasticity and cause a DS behavioural phenotype.
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Thermoresponsive motor behavior is mediated by ring neuron circuits in the central complex of Drosophila.
TL;DR: In this article, trans-Tango mediated transsynaptic tracing together with physiological and behavioral analyses indicate that integrated sensory information of warming is registered by neural activity of R4m as input layer of the ellipsoid body ring neuropil and relayed on to R1 output neurons that gate an adaptive motor response.
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Impaired Pre-Motor Circuit Activity and Movement in a Drosophila Model of KCNMA1-Linked Dyskinesia.
Patrick Kratschmer,Simon Lowe,Edgar Buhl,Ko-Fan Chen,Ko-Fan Chen,Dimitri M. Kullmann,Alan Pittman,James J L Hodge,James E.C. Jepson +8 more
TL;DR: The fruit fly is utilized to study a PxD linked to a gain‐of‐function (GOF) mutation in the KCNMA1/hSlo1 BK potassium channel, which supports a link between BK channel GOF and hyperkinetic movements, and provides a platform to dissect the mechanistic basis of PxDs.
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SlgA, the homologue of the human schizophrenia associated PRODH gene, acts in clock neurons to regulate Drosophila aggression
TL;DR: It is shown that precise regulation of proline metabolism is essential to drive normal behavior and Drosophila aggression is identified as a model behavior relevant for the study of the mechanisms that are impaired in neuropsychiatric disorders.