James J L Hodge

TL;DR: How dendritic growth is vulnerable even to subtle secretory pathway deficits is highlighted, a previously uncharacterized role for Membrin in synaptic function is uncovered, and a comprehensive explanatory basis for genotype-phenotype relationships in GOSR2-PME is provided.

TL;DR: In this paper , the authors investigated the transcriptional and ultrastructural ER and mitochondrial modifications induced by sleep loss and showed that sleep deprivation was associated with significant transcriptional modifications of genes involved in ER stress but also in ER-mitochondria interaction, calcium homeostasis, and mitochondrial respiratory activity.

TL;DR: Drosophila with reduced neuronal expression of the DrosophILA ortholog of human ANK1 (Ank2), can drive AD relevant processes including locomotor difficulties, memory loss and shortened lifespan similar to expression of human amyloid-Beta or tau mutant proteins.

TL;DR: In this article, individual locomotor activity monitoring and colony-wide radio frequency identification tracking are combined to analyze the effects of agrochemicals like neonicotinoids on locomotor and foraging rhythmicity and sleep quantity/quality.

TL;DR: PST-001 effectiveness as a potential new therapeutic targeting AD and DS pathology was demonstrated and targeted overexpression of these AD-associated genes caused degeneration of photoreceptor neurons, shortened lifespan, as well as causing loss of locomotor performance, sleep, and memory.