James N. Ingle

TL;DR: A possible role for megestrol acetate as adjuvant therapy for selected patients with malignant melanoma is suggested, and the most noteworthy side effects were weight gain and impotence.

TL;DR: It is demonstrated for the first time that amplification of Raf/MEK/MAPK oncogenic signaling during tumor growth promotes the genesis of metastatic lesions from primary tumors by activating the mesenchymal to epithelial transition (MET) pathway, although the molecular mechanisms remain elusive.

TL;DR: This study does not establish a significant advantage for the concurrent administration of tamoxifen with the CFP regimen, and the importance of examination of clinically important prognostic factors, even those not utilized in stratification, and consideration of these factors in covariate analysis if imbalances are present is clearly demonstrated.

TL;DR: An optimized five-gene Integrated Cytokine Score (ICS) with multi-platform capability of predicting metastatic outcome from primary HRneg/Tneg tumors independent of nodal status, adjuvant chemotherapy use, and Tneg molecular subtype is derived.

TL;DR: Deleterious variants in cancer susceptibility genes are highly prevalent in patients with invasive breast cancer referred for neoadjuvant chemotherapy undergoing exome sequencing, and Detection of these variants impacts medical management.