Antonino B. D'Assoro

TL;DR: It is demonstrated that independent aspects of centrosome amplification correlate with chromosomal instability and loss of tissue differentiation and may be involved in tumor development and progression and that the centrosomes may be a potential target for cancer therapy.

TL;DR: This review will focus on the diverse roles that GSK-3 plays in various human cancers, in particular in solid tumors, and how this pivotal kinase interacts with multiple signaling pathways.

TL;DR: The role of centrosome amplification in the origin of malignant tumors remains a controversial issue, but several emerging lines of evidence suggest that cell cycle pathways converge on the centrosomes and implicate this organelle in the control of cell cycle progression in addition to its function as a microtubule organizing center.

TL;DR: The targeting of the hormone receptor, HER2 and EGFR1 in breast cancer will be reviewed in association with suppression of the EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway.

TL;DR: Glycogen synthase kinase-3 is a crucial regulatory kinase interacting with multiple pathways to control various physiological processes, as well as leukemia stem cells, leukemia progression and therapeutic resistance.