James N. Ingle

TL;DR: BMI at diagnosis was a statistically significant prognostic factor in a group of patients receiving optimally dosed chemotherapy, and additional research is needed to determine the impact of weight loss on breast cancer outcomes.

TL;DR: The generation of PDX models both sensitive and resistant to standard NAC is feasible and these models exhibit similar biological and drug response characteristics as the patients’ primary tumors, which may be useful for biomarker discovery and future drug development.

TL;DR: Exemestane given for prevention has limited negative impact on menopause-specific and health-related QOL in healthy postmenopausal women at risk for breast cancer.

TL;DR: Assessment of a community cancer control program in Eastern Cooperative Oncology Group demonstrated that 16% of patients surveyed in the affiliated community hospitals were being treated on a research protocol, with a clear relationship between disease stage and age in breast cancer patients.

TL;DR: This study employs the luminal ER+ MCF-7 and the IBC SUM149PT breast cancer cell lines to establish the extent to which high grade of CIN and chemoresistance were mechanistically linked to the enrichment of CD44+/CD24low/− CSCs and proposes a novel therapeutic approach to restore chemosensitivity and delay recurrence of IBC tumors.