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Adriana Donovan
Researcher at Harvard University
Publications - 16
Citations - 9697
Adriana Donovan is an academic researcher from Harvard University. The author has contributed to research in topics: Zebrafish & Ferroportin. The author has an hindex of 14, co-authored 16 publications receiving 8963 citations. Previous affiliations of Adriana Donovan include Boston Children's Hospital & University of Modena and Reggio Emilia.
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Journal ArticleDOI
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Elizabeta Nemeth,Marie S. Tuttle,Julie Powelson,Michael B. Vaughn,Adriana Donovan,Diane M. Ward,Tomas Ganz,Jerry Kaplan +7 more
TL;DR: It is reported that hepcidin bound to ferroportin in tissue culture cells, leading to decreased export of cellular iron and the posttranslational regulation of ferroports by hePCidin may complete a homeostatic loop.
Journal ArticleDOI
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Adriana Donovan,Alison Brownlie,Alison Brownlie,Yi Zhou,Jennifer L. Shepard,Stephen J. Pratt,John Moynihan,Barry H. Paw,Anna Drejer,Bruce A. Barut,Bruce A. Barut,Agustín G. Zapata,Terence C. Law,Carlo Brugnara,Samuel E. Lux,Geraldine S. Pinkus,Jack L. Pinkus,Paul D. Kingsley,James Palis,Mark D. Fleming,Mark D. Fleming,Nancy C. Andrews,Nancy C. Andrews,Leonard I. Zon,Leonard I. Zon +24 more
TL;DR: The gene responsible for the hypochromic anaemia of the zebrafish mutant weissherbst is identified and Ferroportin1 function may be perturbed in mammalian disorders of iron deficiency or overload.
Journal ArticleDOI
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
Adriana Donovan,Adriana Donovan,Christine A. Lima,Christine A. Lima,Jack L. Pinkus,Geraldine S. Pinkus,Leonard I. Zon,Leonard I. Zon,Leonard I. Zon,Sylvie Robine,Nancy C. Andrews,Nancy C. Andrews,Nancy C. Andrews +12 more
TL;DR: Intestine-specific inactivation of ferroportin confirmed that it is critical for intestinal iron absorption and gave insight into hemochromatosis.
Journal ArticleDOI
Vertebrate genome evolution and the zebrafish gene map.
John H. Postlethwait,Yi-Lin Yan,Michael A. Gates,Sally Horne,Angel Amores,Alison Brownlie,Adriana Donovan,Elizabeth S. Egan,Allan Force,Zhiyuan Gong,Carole Goutel,Andreas Fritz,Robert N. Kelsh,Ela W. Knapik,Eric C. Liao,Barry H. Paw,David Ransom,Amy Singer,Margaret Thomson,Tariq S. Abduljabbar,Pamela C. Yelick,D. R. Beier,Jean-Stéphane Joly,Dan Larhammar,Frédéric M. Rosa,Monte Westerfield,Leonard I. Zon,Steve L. Johnson,William S. Talbot +28 more
TL;DR: This zebrafish gene map will facilitate molecular identification of mutated zebra-fish genes, which can suggest functions for human genes known only by sequence, and is likely that two polyploidization events occurred prior to the divergence of fish and mammal lineages.
Journal ArticleDOI
Autosomal-dominant hemochrom-atosis is associated with a mutation in the ferroportin (SLC11A3) gene
Giuliana Montosi,Adriana Donovan,A. Totaro,Cinzia Garuti,Elisa Pignatti,Stefano Cassanelli,Cameron C. Trenor,Paolo Gasparini,Nancy C. Andrews,Antonello Pietrangelo +9 more
TL;DR: It is proposed that partial loss of ferroportin function leads to an imbalance in iron distribution and a consequent increase in tissue iron accumulation, and the iron-loading phenotype in autosomal-dominant hemochromatosis is associated with a nonconservative missense mutation in the ferro portin gene.