J
James R. Plitt
Researcher at Johns Hopkins University
Publications - 9
Citations - 1322
James R. Plitt is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Chemokine & Chemokine receptor. The author has an hindex of 6, co-authored 9 publications receiving 1289 citations.
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Journal ArticleDOI
Activation of Airway Epithelial Cells by Toll-Like Receptor Agonists
TL;DR: The results suggest that airway epithelial cells express several TLRs and that they are functionally active, which may be of importance in inflammation and immunity in the airways in response to inhaled pathogens.
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Atopic dermatitis is associated with a functional mutation in the promoter of the C-C chemokine RANTES
Renate Nickel,Renate Nickel,Vincenzo Casolaro,Ulrich Wahn,Kirsten Beyer,Kirsten Beyer,Kathleen C. Barnes,Beverly Plunkett,Linda R. Freidhoff,Claudia Sengler,James R. Plitt,Robert P. Schleimer,Luis Caraballo,Raana P. Naidu,Paul N. Levett,Terri H. Beaty,Shau Ku Huang +16 more
TL;DR: The findings suggest that the mutant allele of the RANTES gene contributes to the development of atopic dermatitis and its potential role in other inflammatory and infectious disorders, particularly among individuals of African ancestry, remains to be determined.
Journal Article
Activation of Eotaxin Gene Transcription by NF-κB and STAT6 in Human Airway Epithelial Cells
Satoshi Matsukura,Cristiana Stellato,James R. Plitt,Carol A. Bickel,Katsushi Miura,Steve N. Georas,Vincenzo Casolaro,Robert P. Schleimer +7 more
TL;DR: Results imply that TNF-α and IL-4 stimulate expression of the eotaxin gene by activating NF-κB and STAT6.
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Interleukin-13 upregulates eotaxin expression in airway epithelial cells by a STAT6-dependent mechanism.
Satoshi Matsukura,Cristiana Stellato,Steve N. Georas,Vincenzo Casolaro,James R. Plitt,Katsushi Miura,Shin Kurosawa,Ulrike Schindler,Robert P. Schleimer +8 more
TL;DR: It is found that IL-13 upregulated eotaxin messenger RNA and protein synthesis in the airway epithelial cell line BEAS-2B and that STAT6 plays a pivotal role in this response.
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Cutting Edge: Expression of the C-C Chemokine Receptor CCR3 in Human Airway Epithelial Cells
Cristiana Stellato,Mary Brummet,James R. Plitt,Syed Shahabuddin,Fuad M. Baroody,Mark C. Liu,Paul D. Ponath,Lisa A. Beck +7 more
TL;DR: The detection of CCR3 immunoreactivity on epithelial cells in biopsies of patients with asthma and other respiratory diseases suggests that C CR3 ligands may influence epithelial cell functions.