B
Beverly Plunkett
Researcher at Johns Hopkins University
Publications - 25
Citations - 6942
Beverly Plunkett is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Immunoglobulin E & Cytokine. The author has an hindex of 17, co-authored 25 publications receiving 6837 citations. Previous affiliations of Beverly Plunkett include Johns Hopkins University School of Medicine.
Papers
More filters
Journal ArticleDOI
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
Michael B. Kastan,Qimin Zhan,Wafik S. El-Deiry,Tyler Jacks,William V. Walsh,Beverly Plunkett,Bert Vogelstein,Albert J. Fornace +7 more
TL;DR: Three participants are identified (AT gene(s), p53, and GADD45) in a signal transduction pathway that controls cell cycle arrest following DNA damage; abnormalities in this pathway probably contribute to tumor development.
Journal ArticleDOI
Wild-type p53 is a cell cycle checkpoint determinant following irradiation.
TL;DR: Participation of p53 in this pathway suggests a mechanism for the contribution of abnormalities in p53 to tumorigenesis and genetic instability and provides a useful model for studies of the molecular mechanisms of p 53 involvement in controlling the cell cycle.
Journal ArticleDOI
Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage
Theodore D. Kessis,Robert J. Slebos,William G. Nelson,Michael B. Kastan,Beverly Plunkett,Sung M. Han,Attila T. Lorincz,Lora Hedrick,Kathleen R. Cho +8 more
TL;DR: It is demonstrated that oncogenic E6 can disrupt an important cellular response to DNA damage mediated by p53 and may contribute to the subsequent accumulation of genetic changes associated with cervical tumorigenesis.
Journal ArticleDOI
p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.
Robbert J. C. Slebos,Mann H. Lee,Beverly Plunkett,Theodore D. Kessis,Bart O. Williams,Tyler Jacks,Lora Hedrick,Michael B. Kastan,Kathleen R. Cho +8 more
TL;DR: The results suggest that p53 indirectly regulates phosphorylation of pRB and that p RB and/or other pRB-like molecules that bind to HPV16 E7 participate in the DNA damage-mediated G1 arrest signal.
Journal ArticleDOI
Atopic dermatitis is associated with a functional mutation in the promoter of the C-C chemokine RANTES
Renate Nickel,Renate Nickel,Vincenzo Casolaro,Ulrich Wahn,Kirsten Beyer,Kirsten Beyer,Kathleen C. Barnes,Beverly Plunkett,Linda R. Freidhoff,Claudia Sengler,James R. Plitt,Robert P. Schleimer,Luis Caraballo,Raana P. Naidu,Paul N. Levett,Terri H. Beaty,Shau Ku Huang +16 more
TL;DR: The findings suggest that the mutant allele of the RANTES gene contributes to the development of atopic dermatitis and its potential role in other inflammatory and infectious disorders, particularly among individuals of African ancestry, remains to be determined.