J
James R. Woodgett
Researcher at Lunenfeld-Tanenbaum Research Institute
Publications - 325
Citations - 53780
James R. Woodgett is an academic researcher from Lunenfeld-Tanenbaum Research Institute. The author has contributed to research in topics: GSK-3 & Protein kinase A. The author has an hindex of 113, co-authored 319 publications receiving 51191 citations. Previous affiliations of James R. Woodgett include Asahikawa Medical College & Texas A&M University.
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Journal ArticleDOI
The Effects of Glycogen Synthase Kinase-3beta in Serotonin Neurons
Wenjun Zhou,Ligong Chen,Jodi R. Paul,Sufen Yang,Fuzeng Li,Karen Sampson,James R. Woodgett,Jean-Martin Beaulieu,Karen L. Gamble,Xiaohua Li +9 more
TL;DR: Results of this study demonstrated a serotonin neuron-targeting function of GSK3β by regulating 5-HT1B autoreceptors, which impacts serotonergic neuron firing, serotonin release, and serotonin-regulated behaviors.
Journal ArticleDOI
Correction of GSK3β at young age prevents muscle pathology in mice with myotonic dystrophy type 1.
Christina Wei,Lauren Stock,Leila Valanejad,Zachary A. Zalewski,Rebekah Karns,Jack Puymirat,David L. Nelson,David P. Witte,James R. Woodgett,Nikolai A. Timchenko,Lubov Timchenko +10 more
TL;DR: It is shown that the inhibition of GSK3β in young HSALR mice prevents development of DM1 muscle pathology, suggesting that the correction of Gsk3β‐CUGBP1 pathway in young hsalr mice might have a positive effect on the myogenesis over time.
Journal Article
Regulation of jun/AP-1 oncoproteins by protein phosphorylation.
James R. Woodgett,Bernd J. Pulverer,Eleni Nikolakaki,Simon E. Plyte,Kenneth Hughes,C. C. Franklin,A. S. Kraft +6 more
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Glycogen synthase kinase 3α regulates urine concentrating mechanism in mice.
Rikke Nørregaard,Shixin Tao,Line Nilsson,James R. Woodgett,Vijayakumar R. Kakade,Alan S.L. Yu,Christiana Howard,Reena Rao +7 more
TL;DR: It is demonstrated, for the first time, that GSK3α could play a crucial role in renal urine concentration and suggested that G SK3α might be one of the initial targets of Li(+) in LiCl-induced nephrogenic diabetes insipidus.
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A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition.
Dylan Brethour,Mohadeseh Mehrabian,Declan Williams,Xinzhu Wang,Farinaz Ghodrati,Sepehr Ehsani,Sepehr Ehsani,Elizabeth A. Rubie,James R. Woodgett,Jean Sevalle,Zhengrui Xi,Ekaterina Rogaeva,Gerold Schmitt-Ulms +12 more
TL;DR: The data suggests that PrP and ZIP6 inherited the ability to interact with NCAM1 from their common ZIP ancestors but have since diverged to control distinct posttranslational modifications ofNCAM1.