J
James R. Woodgett
Researcher at Lunenfeld-Tanenbaum Research Institute
Publications - 325
Citations - 53780
James R. Woodgett is an academic researcher from Lunenfeld-Tanenbaum Research Institute. The author has contributed to research in topics: GSK-3 & Protein kinase A. The author has an hindex of 113, co-authored 319 publications receiving 51191 citations. Previous affiliations of James R. Woodgett include Asahikawa Medical College & Texas A&M University.
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Journal ArticleDOI
Glycogen Synthase Kinase-3 - An Overview of An Over-Achieving Protein Kinase
TL;DR: This introductory chapter provides a primer on the modes of GSK-3 regulation and a description of the various signaling pathways and cellular processes in which G SK-3 is an active participant.
Journal ArticleDOI
DREAM Is a Critical Transcriptional Repressor for Pain Modulation
Hai-Ying M. Cheng,Graham M. Pitcher,Steven R. Laviolette,Ian Q. Whishaw,Kit I. Tong,Lisa Kockeritz,Teiji Wada,Teiji Wada,Nicholas Joza,Nicholas Joza,Nicholas Joza,Michael A. Crackower,Michael A. Crackower,Michael A. Crackower,Jason Goncalves,Ildiko Sarosi,James R. Woodgett,Antonio J. Oliveira-dos-Santos,Antonio J. Oliveira-dos-Santos,Mitsuhiko Ikura,Derek van der Kooy,Michael W. Salter,Josef M. Penninger +22 more
TL;DR: Mice lacking DREAM had elevated levels of prodynorphin mRNA and dynorphin A peptides in the spinal cord, and the reduction of pain behaviors in dream(-/-) mice was mediated through dynorphIn-selective kappa (kappa)-opiate receptors, and DREAM appears to be a critical transcriptional repressor in pain processing.
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Activation of Akt-1 (PKB-α) Can Accelerate ErbB-2-Mediated Mammary Tumorigenesis but Suppresses Tumor Invasion
TL;DR: Observations suggest that activation of Akt-1 during ErbB-2-induced mammary tumorigenesis may have opposing effects on tumor growth and metastatic progression.
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Tissue-Specific Role of Glycogen Synthase Kinase 3β in Glucose Homeostasis and Insulin Action
Satish Patel,Bradley W. Doble,Bradley W. Doble,Katrina MacAulay,Elaine M. Sinclair,Daniel J. Drucker,James R. Woodgett +6 more
TL;DR: A conditional gene-targeting approach whereby mice in which expression of GSK-3β was specifically ablated within insulin-sensitive tissues were generated was undertaken indicated that there are not only distinct roles for G SKS-3α and GK3β within the adult but also tissue-specific phenotypes associated with each of these isoforms.
Journal ArticleDOI
Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth.
Woo Yang Kim,Feng Quan Zhou,Feng Quan Zhou,Jiang Zhou,Yukako Yokota,Yan Min Wang,Takeshi Yoshimura,Kozo Kaibuchi,James R. Woodgett,Eva S. Anton,William D. Snider +10 more
TL;DR: The results suggest that GSK-3 is a downstream convergent point for many axon growth regulatory pathways and that differential regulation of primed versus all G SKS-3 substrates is associated with a specific morphological outcome.