J
James V. Bruckner
Researcher at University of Georgia
Publications - 96
Citations - 2653
James V. Bruckner is an academic researcher from University of Georgia. The author has contributed to research in topics: Pharmacokinetics & Physiologically based pharmacokinetic modelling. The author has an hindex of 28, co-authored 96 publications receiving 2518 citations. Previous affiliations of James V. Bruckner include University of Cincinnati Academic Health Center.
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Journal ArticleDOI
Metabolism, toxicity, and carcinogenicity of trichloroethylene.
TL;DR: The total amount of TRI metabolized was considered in the most recent EPA Health Assessment Document for Trichloroethylene to be the effective dose (EFD) producing tumors in the liver and there is evidence that formation of reactive intermediate(s) and TRI hepatotoxicity are directly proportional to the overall extent of TRI metabolism.
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Differences in sensitivity of children and adults to chemical toxicity: the NAS panel report.
TL;DR: It was concluded by the NAS committee that immaturity does not necessarily entail greater sensitivity to chemical toxicity; age-dependent toxicity is chemical-dependent; and the existing 10-fold interspecies uncertainty factor provides adequate protection of infants and children, based on current knowledge.
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Characterization of deltamethrin metabolism by rat plasma and liver microsomes
Sathanandam S. Anand,James V. Bruckner,Wendy T. Haines,Wendy T. Haines,Srinivasa Muralidhara,Jeffrey W. Fisher,Stephanie Padilla +6 more
TL;DR: The aims of this study were to identify, characterize, and assess the relative contributions of esterases and cytochrome P450s (CYP450s) responsible for deltamethrin metabolism by measuring deltAMethrin disappearance following incubation of various concentrations in plasma (esterases) and liver microsomes prepared from adult male rats.
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The potential adverse health effects of dental amalgam.
Amy M. Brownawell,Stanley Berent,Robert L. Brent,James V. Bruckner,John Doull,Eric Gershwin,Ronald D. Hood,Genevieve M. Matanoski,Raphael Rubin,Bernard Weiss,Meryl H. Karol +10 more
TL;DR: This review has uncovered no convincing evidence pointing to any adverse health effects that are attributable to dental amalgam restorations besides hypersensitivity in some individuals.
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Development of a Physiologically Based Pharmacokinetic Model for Deltamethrin in the Adult Male Sprague-Dawley Rat
Ahmad Mirfazaelian,Kyu-Bong Kim,Sathanandam S. Anand,Hyo J. Kim,Rogelio Tornero-Velez,James V. Bruckner,Jeffrey W. Fisher +6 more
TL;DR: It became clear from modeling efforts that there is considerably more to be learned about processes that govern GI absorption and exsorption, transport, binding, brain uptake and egress, fat deposition, and systemic elimination of DLT and other pyrethroids.