J
James W. Fristrom
Researcher at University of California, Berkeley
Publications - 81
Citations - 5252
James W. Fristrom is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Imaginal disc & Drosophila melanogaster. The author has an hindex of 41, co-authored 81 publications receiving 5145 citations. Previous affiliations of James W. Fristrom include University of Tennessee & University of California, Los Angeles.
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Journal ArticleDOI
Talin Is Essential for Integrin Function in Drosophila
Nicholas H. Brown,Stephen L. Gregory,Wayne L. Rickoll,Liselotte I. Fessler,Mary Prout,Robert A. H. White,James W. Fristrom +6 more
TL;DR: It is shown that the Drosophila gene rhea encodes talin, which is essential for integrin function and acts by stably linking clusters of ECM-linked integrins to the cytoskeleton.
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Gene within a gene: nested Drosophila genes encode unrelated proteins on opposite DNA strands.
TL;DR: A pupal cuticle protein gene has been found within an intron of a Drosophila gene that encodes three purine pathway enzymatic activities, indicating a housekeeping gene and a developmentally regulated gene function in a nested arrangement.
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Interactions and developmental effects of mutations in the Broad-Complex of Drosophila melanogaster.
TL;DR: Results are presented that indicate that the BR-C contains two major functional domains, and one, the br domain is primarily, if not exclusively, involved in the elongation and eversion of appendages by imaginal discs, and the second, the l(1)2Bc domain, is primarily involvement in the fusion of discs to form a continuous adult epidermis.
Journal ArticleDOI
Cuticle Protein Genes of Drosophila: Structure, Organization and Evolution of Four Clustered Genes
Michael Snyder,Michael W. Hunkapiller,David Yuen,Donald J. Silvert,James W. Fristrom,Norman Davidson +5 more
TL;DR: Most of a 9 kb region of the Drosophila genome containing genes for several cuticle proteins has been sequenced and five cuticle-gene-like sequences have been identified and mapped, and they are discussed as a model small gene family.
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The distribution of PS integrins, laminin A and F-actin during key stages in Drosophila wing development
TL;DR: Wing development during metamorphosis of Drosophila is summarized and four critical steps in the conversion of a folded single layered wing disc to a flat bilayered wing are identified, concluding that laminin is not a ligand for integrin in this context.