J
James W. Young
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 208
Citations - 15148
James W. Young is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 59, co-authored 204 publications receiving 14046 citations. Previous affiliations of James W. Young include Kettering University & University of Arkansas for Medical Sciences.
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Journal ArticleDOI
Predominant Autoantibody Production by Early Human B Cell Precursors
Hedda Wardemann,Sergey Yurasov,Sergey Yurasov,Anne Schaefer,James W. Young,Eric Meffre,Eric Meffre,Michel C. Nussenzweig,Michel C. Nussenzweig +8 more
TL;DR: The prevalence of self-reactive antibody formation and its regulation in human B cells is determined and a majority (55 to 75%) of all antibodies expressed by early immature B cells displayedSelf-reactivity, including polyreactive and anti-nuclear specificities.
Journal ArticleDOI
Infusions of Donor Leukocytes to Treat Epstein-Barr Virus-Associated Lymphoproliferative Disorders after Allogeneic Bone Marrow Transplantation
Esperanza B. Papadopoulos,Marc Ladanyi,David Emanuel,Stephen Mackinnon,Farid Boulad,Matthew H. Carabasi,Hugo Castro-Malaspina,Barrett H. Childs,Alfred P. Gillio,Trudy N. Small,James W. Young,Nancy A. Kernan,Richard J. O'Reilly +12 more
TL;DR: In a small number of patients, infusions of unirradiated donor leukocytes were an effective treatment for EBV-associated lymphoproliferative disease that arose after allogeneic bone marrow transplantation.
Journal ArticleDOI
Telomerase activity in normal and malignant hematopoietic cells.
TL;DR: Data indicate that human telomerase is not restricted to immortal cells and suggest that the somatic expression of this enzyme may be more widespread than was previously inferred from the decline of human telomeres.
Journal ArticleDOI
Sirolimus and kidney growth in autosomal dominant polycystic kidney disease.
Andreas L. Serra,Diane Poster,Andreas D. Kistler,Fabienne Krauer,Shagun Raina,James W. Young,Katharina Rentsch,Katharina Spanaus,Oliver Senn,Paulus Kristanto,Hans Scheffel,Dominik Weishaupt,Rudolf P. Wüthrich +12 more
TL;DR: In adults with ADPKD and early chronic kidney disease, 18 months of treatment with sirolimus did not halt polycystic kidney growth and the glomerular filtration rate did not differ significantly between the two groups; however, the urinary albumin excretion rate was higher in the siro Limus group.
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Comparison of immune reconstitution after unrelated and related T-cell-depleted bone marrow transplantation : Effect of patient age and donor leukocyte infusions
Trudy N. Small,Esperanza B. Papadopoulos,Farid Boulad,P Black,Hugo Castro-Malaspina,Barrett H. Childs,Nancy H. Collins,Alfred P. Gillio,Daniel J. George,Ann A. Jakubowski,Glenn Heller,Melissa Fazzari,Nancy A. Kernan,Stephen Mackinnon,Paul Szabolcs,James W. Young,R.J. O'Reilly +16 more
TL;DR: It is demonstrated that adult recipients of TCD unrelated BMTs experience prolonged and profound deficiencies of CD3(+, CD4(+), and CD8(+) T-cell populations when compared with pediatric recipients of unrelated B MT and adults after related BMT, and that these adults have a significantly increased risk of life-threatening opportunistic infections.