Jamie L. Gilmore

TL;DR: An overview of novel nanomaterials that have potential to improve diagnosis and therapy of neurodegenerative disorders and how to enable these materials to cross the blood brain barrier will allow efficient systemic delivery of therapeutic and diagnostic agents to the brain.

TL;DR: A model in which the EcoRII restriction enzyme employs a three-site binding mechanism to catalyze cleavage of a single recognition site is proposed, which is involved in the formation and dynamics of a catalytically active three- site complex.

TL;DR: It is proposed that the SfiI tetramer can remain bound to one of the sites even after cleavage, allowing the other site on the DNA molecule to fill the empty DNA-binding cleft by combining a one-dimensional diffusion-mediated sliding and a segment transfer mechanism.

TL;DR: Atomic force microscopy was used to test this model for the EcoRII restriction enzyme and provide direct visualization and characterization of synaptic protein-DNA complexes involving three DNA binding sites, and showed that the dimeric form of the protein is responsible for the formation of other types of synaptic complexes.

TL;DR: A combined atomic force/optical microscope system is used to analyze membrane‐based cellular events at nanometer‐scale resolution in live cells to provide novel insights into the structural aspects of the entire cell membrane machinery which can be visualized with high temporal and spatial resolution.