L
Ling Dong Quan
Researcher at University of Nebraska Medical Center
Publications - 12
Citations - 1157
Ling Dong Quan is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Arthritis & Nanomedicine. The author has an hindex of 12, co-authored 12 publications receiving 1025 citations.
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Journal ArticleDOI
Novel nanomaterials for clinical neuroscience.
TL;DR: An overview of novel nanomaterials that have potential to improve diagnosis and therapy of neurodegenerative disorders and how to enable these materials to cross the blood brain barrier will allow efficient systemic delivery of therapeutic and diagnostic agents to the brain.
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The Development of Novel Therapies for Rheumatoid Arthritis.
TL;DR: During the past 20 years, most of the development of new therapies in antirheumatic therapies is in DMARDs, especially biologicalDMARDs.
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Development of macromolecular prodrug for rheumatoid arthritis.
TL;DR: This manuscript provides a comprehensive overview of the rational design and optimization of macromolecular prodrugs for treatment of RA and illustrates the potential benefits of applying this therapeutic strategy to the treatment of other inflammatory diseases.
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Nanomedicines for Inflammatory Arthritis: Head-to-Head Comparison of Glucocorticoid-Containing Polymers, Micelles, and Liposomes
Ling Dong Quan,Yijia Zhang,Bart J Crielaard,Anand Dusad,Subodh M. Lele,Cristianne J.F. Rijcken,Josbert M. Metselaar,Hana Kostková,Tomáš Etrych,Karel Ulbrich,Fabian Kiessling,Ted R. Mikuls,Wim E. Hennink,Gert Storm,Gert Storm,Twan Lammers,Twan Lammers,Twan Lammers,Dong Wang +18 more
TL;DR: It was found that after a single i.v. injection, the formulations with the slower drug release Kinetics maintained longer duration of therapeutic activity than those with relatively faster drug release kinetics, resulting in better joint protection.
Journal ArticleDOI
Glucocorticoid-Loaded Core-Cross-Linked Polymeric Micelles with Tailorable Release Kinetics for Targeted Therapy of Rheumatoid Arthritis
Bart J Crielaard,Cristianne J.F. Rijcken,Ling Dong Quan,Steffen van der Wal,Isil Altintas,Martin van der Pot,John A. W. Kruijtzer,Rob M. J. Liskamp,Raymond M. Schiffelers,Cornelus F. van Nostrum,Wim E. Hennink,Dong Wang,Twan Lammers,Twan Lammers,Gert Storm,Gert Storm +15 more
TL;DR: Polymerizable and hydrolytically cleavable dexamethasone derivatives were covalently entrapped in core-cross-linked polymeric micelles that were prepared from a thermosensitive block copolymer.