R
Roger J. S. Preston
Researcher at Royal College of Surgeons in Ireland
Publications - 79
Citations - 2231
Roger J. S. Preston is an academic researcher from Royal College of Surgeons in Ireland. The author has contributed to research in topics: Von Willebrand factor & Medicine. The author has an hindex of 24, co-authored 62 publications receiving 1670 citations. Previous affiliations of Roger J. S. Preston include Boston Children's Hospital & Imperial College London.
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Journal ArticleDOI
Persistent Endotheliopathy in the Pathogenesis of Long COVID Syndrome.
Helen Fogarty,Liam Townsend,Hannah Morrin,Azaz Ahmad,Claire Comerford,Ellie Karampini,Hanna Englert,Mary Byrne,Colm Bergin,Jamie M. O’Sullivan,Ignacio Martin-Loeches,Parthiban Nadarajan,Ciaran Bannan,Patrick W. G. Mallon,Gerard F. Curley,Roger J. S. Preston,Roger J. S. Preston,Aisling M. Rehill,Dennis McGonagle,Dennis McGonagle,Cliona Ni Cheallaigh,Ross I. Baker,Thomas Renné,Thomas Renné,Soracha E. Ward,James S. O’ Donnell +25 more
TL;DR: In this paper, the authors assess whether endothelial cell activation may be sustained in convalescent COVID-19 patients and contribute to long COVID pathogenesis, and demonstrate that sustained endotheliopathy was more frequent in older, comorbid patients and those requiring hospitalization.
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Multifunctional Specificity of the Protein C/Activated Protein C Gla Domain
Roger J. S. Preston,Éva Ajzner,Cristina Razzari,Cristina Razzari,Stalo Karageorgi,Sonia Dua,Björn Dahlbäck,David A. Lane +7 more
TL;DR: Results reveal the specific Gla domain residues responsible for mediating protein C/APC molecular recognition with both its cofactor and receptor and further illustrate the multifunctional potential of Gla domains.
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Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet-decorated von Willebrand factor strings
Daniel J. Bridges,James Bunn,James Bunn,Jan A. van Mourik,Georges E. Grau,Roger J. S. Preston,Malcolm E. Molyneux,Valery Combes,James S. O’Donnell,Bas de Laat,Alister Craig +10 more
TL;DR: This study demonstrates tethering and firm adhesion of IEs to the endothelium specifically at sites of platelet accumulation and proposes that this new mechanism contributes to sequestration both independently of and in concert with current adhesion mechanisms.
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Severe Plasmodium falciparum Malaria Is Associated with Circulating Ultra-Large von Willebrand Multimers and ADAMTS13 Inhibition
Deirdre Larkin,Bas de Laat,P. Vince Jenkins,James Bunn,Alister Craig,Virginie Terraube,Roger J. S. Preston,Cynthia Donkor,Cynthia Donkor,George E. Grau,Jan A. van Mourik,James S. O’Donnell +11 more
TL;DR: The novel findings suggest that severe P. falciparum infection is associated with acute endothelial cell activation, abnormal circulating ULVWF multimers, and a significant reduction in plasma ADAMTS13 function which is mediated at least in part by an unidentified inhibitor.
Journal ArticleDOI
Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation.
Fionnuala Ní Áinle,Roger J. S. Preston,P. Vincent Jenkins,Hendrik J. Nel,Jennifer Johnson,Owen P. Smith,Barry White,Padraic G. Fallon,James S. O’Donnell +8 more
TL;DR: Low-dose protamine effectively reversed the anticoagulant activity of unfractionated heparin in plasma, and elevated protamine concentrations were associated with progressive dose-dependent reduction in thrombin generation.