Jan-Bernd Funcke

TL;DR: The diverse signaling mediators and mechanisms adipose tissue utilizes to relay information to other organs are reviewed and recently identified adipokines (proteins, lipids, and metabolites) are discussed and the contributions of noncoding RNAs and EVs to the ever-increasing complexities of adipose tissues inter-organ communication are outlined.

TL;DR: Treating a 2-year-old boy with early-onset extreme obesity due to a novel homozygous transversion in LEP with recombinant human leptin (metreleptin) rapidly normalized eating behavior and resulted in weight loss.

TL;DR: In this paper, the authors found that adipocytes respond to mitochondrial stress by rapidly and robustly releasing small extracellular vesicles (sEVs), which contain respiration-competent, but oxidatively damaged mitochondrial particles, which enter circulation and are taken up by cardiomyocytes, where they trigger a burst of ROS.

TL;DR: It is shown that miR-146a reduces the inflammatory response in human adipocytes, which might contribute to the regulation of inflammatory processes in WAT and possibly prevent an overwhelming inflammatory response.

TL;DR: This review describes the molecular and cellular characteristics of the eight distinct mutations found so far in humans caused by mutations in the leptin gene.