Tomas Tanskanen

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: Analysis of public data showed that multiple cancer types accumulate CBS mutations, and integration of whole-genome sequencing data from 213 colorectal cancer samples and chromatin immunoprecipitation sequencing data identified frequent point mutations at CBSs.

TL;DR: In this article, the authors reported a genome-wide association analysis of 34,627 colorectal cancer cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci.

TL;DR: The results indicate that in addition to ARID1A, other members of the ARID gene family may play a role in MSI CRC, and the mutations were distributed along the entire length of the gene, thus distinguishing them from typical MSI target genes previously described.

TL;DR: The study provides a set of candidate predisposition genes which may explain a subset of common familial CRC cases, and additional genetic validation in other populations is required to provide firm evidence for causality.