M
Minna Taipale
Researcher at Karolinska Institutet
Publications - 34
Citations - 3845
Minna Taipale is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Gene & Exome sequencing. The author has an hindex of 20, co-authored 33 publications receiving 3113 citations. Previous affiliations of Minna Taipale include Science for Life Laboratory & University of Cambridge.
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Journal ArticleDOI
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Yimeng Yin,Ekaterina Morgunova,Arttu Jolma,Eevi Kaasinen,Biswajyoti Sahu,Syed Khund-Sayeed,Pratyush Kumar Das,Teemu Kivioja,Kashyap Dave,Fan Zhong,Kazuhiro R. Nitta,Minna Taipale,Alexander Popov,Paul A. Ginno,Silvia Domcke,Silvia Domcke,Jian Yan,Dirk Schübeler,Dirk Schübeler,Charles Vinson,Jussi Taipale,Jussi Taipale +21 more
TL;DR: This work systematically analyzed binding specificities of full-length transcription factors and extended DNA binding domains to unmethylated and CpG-methylated DNA by using methylation-sensitive SELEX (systematic evolution of ligands by exponential enrichment).
Journal ArticleDOI
MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.
Netta Mäkinen,Miika Mehine,Jaana Tolvanen,Eevi Kaasinen,Yang Li,Heli J. Lehtonen,Massimiliano Gentile,Jian Yan,Martin Enge,Minna Taipale,Minna Taipale,Mervi Aavikko,Riku Katainen,Elina Virolainen,Tom Böhling,Tom Böhling,Taru A. Koski,Virpi Launonen,Jari Sjöberg,Jussi Taipale,Jussi Taipale,Pia Vahteristo,Lauri A. Aaltonen +22 more
TL;DR: It is determined that MED12 is altered in 70% (159 of 225) of tumors from a total of 80 patients, and aberrant function of this region of MED12 contributes to tumorigenesis.
Journal ArticleDOI
DNA-dependent formation of transcription factor pairs alters their binding specificity
Arttu Jolma,Yimeng Yin,Kazuhiro R. Nitta,Kashyap Dave,Alexander Popov,Minna Taipale,Martin Enge,Teemu Kivioja,Ekaterina Morgunova,Jussi Taipale,Jussi Taipale +10 more
TL;DR: The results indicate that the DNA molecule commonly plays an active role in cooperative interactions that define the gene regulatory lexicon.
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Transcription Factor Binding in Human Cells Occurs in Dense Clusters Formed around Cohesin Anchor Sites
Jian Yan,Martin Enge,Tom Whitington,Kashyap Dave,Jianping Liu,Inderpreet Sur,Bernhard Schmierer,Arttu Jolma,Teemu Kivioja,Teemu Kivioja,Minna Taipale,Minna Taipale,Jussi Taipale,Jussi Taipale +13 more
TL;DR: The binding pattern of expressed TFs in human colorectal cancer cells is analyzed and it is found that binding of TFs is highly clustered and that the clusters are enriched in binding motifs for several major TF classes.
Journal ArticleDOI
Identification of pathways regulating cell size and cell-cycle progression by RNAi
Mikael Björklund,Minna Taipale,Markku Varjosalo,Juha Saharinen,Juhani Lahdenperä,Jussi Taipale +5 more
TL;DR: This work analyses the effect of the loss of function of 70% of Drosophila genes on cell-cycle progression of S2 cells using flow cytometry and identifies a translational regulator, eIF-3p66, that specifically affects the Cyclin/Cdk pathway activity.