J
Jan Budczies
Researcher at University Hospital Heidelberg
Publications - 185
Citations - 16222
Jan Budczies is an academic researcher from University Hospital Heidelberg. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 48, co-authored 166 publications receiving 12762 citations. Previous affiliations of Jan Budczies include German Cancer Research Center & Humboldt University of Berlin.
Papers
More filters
Journal ArticleDOI
DUSP4 is associated with increased resistance against anti-HER2 therapy in breast cancer.
Otília Menyhárt,Jan Budczies,Gyöngyi Munkácsy,Francisco J. Esteva,András Szabó,Teresa Puig Miquel,Balázs Győrffy +6 more
TL;DR: The findings suggest that DUSP4 may represent a new potential target to overcome trastuzumab resistance, and MAPK phosphatases are essential regulators of MAPKs and participate in many facets of cellular regulation, including proliferation and apoptosis.
Journal ArticleDOI
Prognostic impact of AMP-activated protein kinase expression in ovarian carcinoma: Correlation of protein expression and GC/TOF-MS-based metabolomics
Ann Christin Buckendahl,Jan Budczies,Oliver Fiehn,Silvia Darb-Esfahani,Tobias Kind,Aurelia Noske,Wilko Weichert,Jalid Sehouli,Elena Ioana Braicu,Manfred Dietel,Carsten Denkert +10 more
TL;DR: The results indicate a role for AMPK in progression of ovarian tumors and point towards a prognostic impact of AMPK expression for patient overall survival and suggest a deregulation of the AMPK-dependent energy metabolism in human ovarian carcinomas.
Journal ArticleDOI
RNA-based determination of ESR1 and HER2 expression and response to neoadjuvant chemotherapy
Carsten Denkert,S. Loibl,Ralf Kronenwett,Jan Budczies,C. von Törne,Valentina Nekljudova,Silvia Darb-Esfahani,C. Solbach,Bruno Valentin Sinn,Christoph Petry,B. M. Müller,Jörn Hilfrich,Gabriela Altmann,Annette Staebler,Claudia Roth,Beyhan Ataseven,Thomas Kirchner,Manfred Dietel,Michael Untch,G. von Minckwitz +19 more
TL;DR: Results suggest that mRNA levels of ESR1 and HER2 predict response to neoadjuvant chemotherapy and are significantly associated with long-term outcome.
Posted Content
Towards computational fluorescence microscopy: Machine learning-based integrated prediction of morphological and molecular tumor profiles.
Alexander Binder,Michael Bockmayr,Miriam Hägele,Stephan Wienert,Daniel Heim,Katharina Hellweg,Albrecht Stenzinger,Laura Parlow,Jan Budczies,Benjamin Goeppert,Denise Treue,Manato Kotani,Masaru Ishii,Manfred Dietel,Andreas C. Hocke,Carsten Denkert,Klaus-Robert Müller,Frederick Klauschen +17 more
TL;DR: This integration of microanatomic information of tumors with complex molecular profiling data, including protein or gene expression, copy number variation, gene methylation and somatic mutations, provides a novel means to computationally score molecular markers with respect to their relevance to cancer and their spatial associations within the tumor microenvironment.
Journal ArticleDOI
Artificial intelligence and pathology: From principles to practice and future applications in histomorphology and molecular profiling.
Albrecht Stenzinger,Albrecht Stenzinger,Albrecht Stenzinger,Maximilian Alber,Frederick Klauschen,Ray Jones,Michael Allgäuer,Philipp Jurmeister,Michael Bockmayr,Jan Budczies,Jochen K. Lennerz,Johannes Eschrich,Daniel Kazdal,Peter Schirmacher,Alex H. Wagner,Frank Tacke,David Capper,Klaus-Robert Müller,Frederick Klauschen,Frederick Klauschen,Frederick Klauschen +20 more
TL;DR: In this article, the authors review the pertinent literature of AI methods and their applications to pathology, and put the current achievements and what can be expected in the future in the context of the requirements for research and routine diagnostics.