J
Jan Budczies
Researcher at University Hospital Heidelberg
Publications - 185
Citations - 16222
Jan Budczies is an academic researcher from University Hospital Heidelberg. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 48, co-authored 166 publications receiving 12762 citations. Previous affiliations of Jan Budczies include German Cancer Research Center & Humboldt University of Berlin.
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Journal ArticleDOI
What turns CREB on? And off? And why does it matter?
André Steven,Michael Friedrich,Paul Jank,Nadine Heimer,Jan Budczies,Carsten Denkert,Barbara Seliger +6 more
TL;DR: The clinical relevance of CREB is summarized, including its use as a prognostic and/or predictive marker as well as a therapeutic target.
Journal ArticleDOI
Combined targeted DNA and RNA sequencing of advanced NSCLC in routine molecular diagnostics: Analysis of the first 3,000 Heidelberg cases.
Anna-Lena Volckmar,Jonas Leichsenring,Martina Kirchner,Petros Christopoulos,Olaf Neumann,Jan Budczies,Cristiano Oliveira,Eugen Rempel,Ivo Buchhalter,Ivo Buchhalter,Regine Brandt,Michael Allgäuer,Suranand Babu Talla,Moritz von Winterfeld,Esther Herpel,Benjamin Goeppert,Amelie Lier,Hauke Winter,Tilman Brummer,Tilman Brummer,Stefan Fröhling,M. Faehling,Jürgen Fischer,Claus Peter Heußel,Felix Herth,Felix Lasitschka,Peter Schirmacher,Michael Thomas,Volker Endris,Roland Penzel,Albrecht Stenzinger +30 more
TL;DR: The reliability, low dropout rates, minimal tissue requirements, fast turnaround times and lower costs of the diagnostic approach presented here compared to sequential single‐gene testing, highlight its practicability in order to support individualized decisions in routine patient care, enrollment in molecularly stratified clinical trials, as well as translational research.
Journal ArticleDOI
Phospho-mTOR and phospho-4EBP1 in endometrial adenocarcinoma: association with stage and grade in vivo and link with response to rapamycin treatment in vitro
Silvia Darb-Esfahani,Areeg Faggad,Aurelia Noske,Wilko Weichert,Ann-Christin Buckendahl,Berit Maria Müller,Jan Budczies,Annika Röske,Manfred Dietel,Carsten Denkert +9 more
TL;DR: It is suggested that the expression of elements of the mTOR pathway in human tumor tissue should be further evaluated as a possible predictive marker in large-scale clinical studies as well as translational research protocols in clinical studies with mTOR inhibitors.
Journal ArticleDOI
Integration of metabolomics and expression of glycerol-3-phosphate acyltransferase (GPAM) in breast cancer-link to patient survival, hormone receptor status, and metabolic profiling.
Scarlet F. Brockmöller,Elmar Bucher,Berit Maria Müller,Jan Budczies,Mika Hilvo,Julian L. Griffin,Matej Orešič,Olli Kallioniemi,Kristiina Iljin,Sibylle Loibl,Silvia Darb-Esfahani,Bruno Valentin Sinn,Frederick Klauschen,Judith Prinzler,Nikola Bangemann,Fakher Ismaeel,Oliver Fiehn,Manfred Dietel,Carsten Denkert +18 more
TL;DR: It is suggested that GPAM is expressed in human breast cancer with associated changes in the cellular metabolism, in particular an increased synthesis of phospholipids, the major structural component of cellular membranes.
Journal ArticleDOI
The EndoPredict Gene-Expression Assay in Clinical Practice - Performance and Impact on Clinical Decisions
Berit Maria Müller,Elke Keil,Annika Lehmann,Klaus Jürgen Winzer,Christiane Richter-Ehrenstein,Judith Prinzler,Nikola Bangemann,Angela Reles,Sylvia Stadie,Winfried Schoenegg,Jan Eucker,Marcus Schmidt,Frank Lippek,Korinna Jöhrens,Stefan Pahl,Bruno Valentin Sinn,Jan Budczies,Manfred Dietel,Carsten Denkert +18 more
TL;DR: The results show that the EndoPredict assay could be routinely performed in decentral molecular pathology laboratories and the results markedly change treatment decisions.