Jan Budczies

TL;DR: In this paper , the authors performed multi-region sampling (2-4 samples per tumor; total of 55 samples) from a cohort of 19 untreated stage IA-IIIB lung adenocarcinomas (n = 11 KRAS mutant, n = 1 ERBB2 mutant and n = 7 KRAS wildtype).

TL;DR: New protocols for RNA processing of FFPE specimens revealed similar results as compared to the frozen tissue samples, which appears to be surprising given the fact that formalin fixation produces significant chemical modification of the RNA that depends on fixation conditions and times.

TL;DR: In this paper , a comprehensive mRNA expression analysis in 24 cancer types of TCGA was performed to extract a consensus expression signature shared across TP53 mutation types and cancer types, and differential gene expression patterns between tumors harboring different TP53 mutations such as loss of function, gain of function or dominant negative mutations, and cancer-type specific patterns of gene expression and immune infiltration.

TL;DR: Key aspects and applications of each method are summarized and discussed, and all approved predictive biomarkers and molecular targets, including gene fusions and copy number alterations, can be identified depending on panel design and method applied.

TL;DR: The Altmetric Attention Score as discussed by the authors is a quantitative measure of the attention that a research article has received online, and it is calculated using the Alt-Metric Attention Index (AUI) metric.