J
Jan Kučera
Researcher at Charles University in Prague
Publications - 15
Citations - 210
Jan Kučera is an academic researcher from Charles University in Prague. The author has contributed to research in topics: Melanoma & Self-healing hydrogels. The author has an hindex of 8, co-authored 15 publications receiving 156 citations. Previous affiliations of Jan Kučera include First Faculty of Medicine, Charles University in Prague.
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Journal ArticleDOI
Multispecies biofilm in an artificial wound bed—A novel model for in vitro assessment of solid antimicrobial dressings
TL;DR: A simple and cost-effective in vitro model of chronic wound biofilm applied for testing treatments and solid devices, especially wound dressings, is presented and indicates that this method enables assessing the effects of treatments on established resilient wound biofilms and is clinically highly relevant.
Journal ArticleDOI
Chondrogenic differentiation of mesenchymal stem cells in a hydrogel system based on an enzymatically crosslinked tyramine derivative of hyaluronan.
Jana Dvořáková,Lukáš Kučera,Jan Kučera,Karol Švík,Marcela Foglarová,Tomáš Muthný,Martin Pravda,Miroslava Němcová,Vladimír Velebný,Lukáš Kubala +9 more
TL;DR: MSC chondrogenic differentiation may proceed in a HA-TA scaffold that is biocompatible, and in both cases, in vivoHA-TA implants were continuously degraded and MSC-seeded hydrogels tended to form clusters similar to in vitro samples.
Journal ArticleDOI
A porcine model of skin wound infected with a polybacterial biofilm.
Pavel Klein,Martin Sojka,Jan Kučera,Jana Matonohova,Vojtech Pavlik,Jan Nemec,Gabriela Kubickova,Rastislav Slavkovsky,Katarzyna Maria Szuszkiewicz,Petr Danek,Miroslav Rozkot,Vladimir Velebny +11 more
TL;DR: This model provides a therapeutic one-week window for testing of anti-biofilm treatments and for research on the pathogenesis of wound infections in pig that is clinically the most relevant animal wound healing model.
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Microenvironment‑driven resistance to B‑Raf inhibition in a melanoma patient is accompanied by broad changes of gene methylation and expression in distal fibroblasts.
Ondřej Kodet,Barbora Dvořánková,Běla Bendlová,Vlasta Sýkorová,Ivana Krajsová,Jiří Štork,Jan Kučera,Pavol Szabo,Hynek Strnad,Michal Kolář,Čestmír Vlček,Karel Smetana,Lukáš Lacina +12 more
TL;DR: The present results support recent experimental findings that tumor microenvironment is driving resistance to B-Raf inhibition in patients with melanoma and may be viable for the growth of circulating melanoma cells.
Journal ArticleDOI
Cutaneous melanoma dissemination is dependent on the malignant cell properties and factors of intercellular crosstalk in the cancer microenvironment (Review).
Ondřej Kodet,Jan Kučera,Karolína Strnadová,Barbora Dvořánková,Jiří Štork,Lukáš Lacina,Karel Smetana +6 more
TL;DR: Data on the microenvironment of cutaneous malignant melanoma with emphasis on intercellular signalling during the disease progression is summarised and the concept of melanoma early becoming a systemic disease is presented.