Pavol Szabo

TL;DR: Data is summarized about the possible molecular mechanism influencing rapid spreading of tumors in the elderly population and the role of cancer stroma in controlling multiple biological properties of tumors is a prospective target for translational research with potential therapeutic outcomes.

TL;DR: Considering an analogy between wound healing and tumour progression, chemokine and cytokine transcription and expression in normal fibroblasts is studied by co‐culture and in situ.

TL;DR: In squamous cell carcinomas of head and neck, upregulation of galectin‐1 presence was highly significantly correlated to presence of smooth muscle actin‐positive cancer‐associated fibroblasts in the tumor (p = 4 × 10−8), and microarray analyses to the transcription profiles of the corresponding tumors provided new insights into the significance of presence of myofibroblast in squamouscell carcinoma.

TL;DR: The differential potential of certain human galectins to induce the conversion of dermal fibroblasts into MFBs and the generation of a bioactive cell culture substratum is described.

TL;DR: This model reflects various biological aspects of interaction between cancer cell and CAFs with multiple parallels to interaction of normal epidermal stem cells and their niche and the therapeutic consequences of targeting of microenvironment in anticancer therapy and for improved wound healing are included to article.