J
Jan Zoll
Researcher at Radboud University Nijmegen
Publications - 56
Citations - 2064
Jan Zoll is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Aspergillus fumigatus & RNA. The author has an hindex of 23, co-authored 52 publications receiving 1760 citations. Previous affiliations of Jan Zoll include Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
MDA5 Detects the Double-Stranded RNA Replicative Form in Picornavirus-Infected Cells
Qian Feng,Stanleyson V. Hato,Martijn A. Langereis,Jan Zoll,Richard Virgen-Slane,Alys Peisley,Sun Hur,Bert L. Semler,Ronald P. van Rij,Frank J.M. van Kuppeveld +9 more
TL;DR: This study dissected the IFN-α/β-stimulatory activity of different viral RNA species produced during picornavirus infection, both by RNA transfection and in infected cells in which specific steps of viral RNA replication were inhibited.
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Saffold virus, a human Theiler's-like cardiovirus, is ubiquitous and causes infection early in life.
Jan Zoll,Sandra Erkens Hulshof,Kjerstin Lanke,Frans M. Verduyn Lunel,Willem J. G. Melchers,Esther Schoondermark-van de Ven,Merja Roivainen,Jochem M. D. Galama,Frank J. M. van Kuppeveld +8 more
TL;DR: It is shown that infection by SAFV-3 occurs early in life and that the seroprevalence reaches >90% in older children and adults, and Neutralizing antibodies were found in serum samples collected in several countries in Europe, Africa, and Asia.
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The mengovirus leader protein blocks interferon-alpha/beta gene transcription and inhibits activation of interferon regulatory factor 3.
Stanleyson V. Hato,Céline Ricour,Barbara M. Schulte,Kjerstin Lanke,Mike A. M. De Bruijni,Jan Zoll,Willem J. G. Melchers,Thomas Michiels,Frank J. M. van Kuppeveld +8 more
TL;DR: It is suggested that the leader, by suppressing IRF3‐mediated IFN‐α/β production, plays an important role in replication and dissemination of mengovirus in its host.
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A novel environmental azole resistance mutation in Aspergillus fumigatus and a possible role of sexual reproduction in its emergence
Jianhua Zhang,Eveline Snelders,Bas J. Zwaan,Sijmen E. Schoustra,Jacques F. Meis,Karin van Dijk,Ferry Hagen,Martha T. van der Beek,Greetje A. Kampinga,Jan Zoll,Willem J. G. Melchers,Paul E. Verweij,Alfons J. M. Debets +12 more
TL;DR: It is confirmed that azole resistance mutations continue to emerge in the environment and indicates compost containing azole residues as a possible hot spot, and the discovery of a new resistance mutation with clinical relevance is shown.
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Coxsackie B3 virus protein 2B contains cationic amphipathic helix that is required for viral RNA replication.
TL;DR: It is shown that both the amphipathy of the domain and the presence of cationic residues in the hydrophilic face of the alpha-helix are required for virus growth and mutations that disturbed either one of these features caused defects in viral RNA synthesis.